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A TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer

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Author(s)
Deok Heon LeeYu-Ran HeoWon-Jin ParkJae-Ho Lee
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Pathology - Research and Practice
Issued Date
2017
Volume
213
Issue
11
Keyword
CLPTM1L polymorphismLung cancerNSCLCTERT-CLPTM1L locusTelomere length
Abstract
Telomere length is associated with lung carcinogenesis, and recent studies have focused on telomere-maintaining genes and their polymorphisms. Cancer susceptibility of the rs401681 polymorphism, located in the TERT-CLPTM1L locus, has been studied in many cancers. We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer. The relationship between rs401681 variants and telomere length was analyzed in 134 non-small cell lung cancers (NSCLCs). The rs401681 polymorphism had the following genotype frequencies: C/C in 52.2% of the samples, C/T in 30.6%, and T/T in 17.2%. The T allele showed a strong correlation with EGFR mutation (p=0.037). Telomeres in the tumor samples were 3.26-fold longer, on average, than telomeres in matched normal samples (SD=0.48), and there were no differences in telomere length according to rs401681 polymorphism. Smoking was associated with telomere shortening (p=0.01). Survival analysis showed no prognostic value for rs401681 polymorphisms or telomere length in NSCLC. These results suggested that the rs401681 polymorphism contributes to lung carcinogenesis only in patients harboring an EGFR mutation. However, the polymorphism was not associated with survival; therefore, further comprehensive analysis should be performed.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
Deok Heon Lee et al. (2017). A TERT-CLPTM1 locus polymorphism (rs401681) is associated with EGFR mutation in non-small cell lung cancer. Pathology - Research and Practice, 213(11), 1340–1343. doi: 10.1016/j.prp.2017.09.028
Type
Article
ISSN
0344-0338
Source
https://linkinghub.elsevier.com/retrieve/pii/S0344033817307288
DOI
10.1016/j.prp.2017.09.028
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41049
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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