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Anti-inflammatory effects of ursolic acid-3-acetate on human synovial fibroblasts and a murine model of rheumatoid arthritis.

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Author(s)
Jong Yeong LeeJin Kyeong ChoiNa-Hee JeongJeongsoo YooYeong Su HaByungheon LeeHyukjae ChoiPil-Hoon ParkTae-Yong ShinTaeg Kyu KwonSang-Rae LeeSoyoung LeeSeung Woon LeeMun-Chua RhoiSang-Hyun Kim
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
International Immunopharmacology
Issued Date
2017
Volume
49
Keyword
Collagen-induced arthritisInflammatory cytokineLymph nodesMatrix metalloproteinaseSynovial fibroblastsUrsolic acid-3-acetate
Abstract
Ursolic acid (UA), a pentacyclic triterpenoid, is a common natural substance known to be effective in the treatment of inflammation, oxidative stress, and ulcers in arthritis. This study examined the effects of ursolic acid-3-acetate (UAA), a derivative of UA, on rheumatoid arthritis (RA) and verified the underlying mechanism of action by using a type-II collagen-induced arthritis (CIA) mice model and tumor necrosis factor (TNF)-α-stimulated RA synovial fibroblasts. The oral administration of UAA showed a decrease in clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum IgG1 and IgG2a levels. UAA administration reduced Th1/Th17 phenotype CD4+ T lymphocyte expansion and inflammatory cytokine production in draining lymph nodes. In addition, UAA effectively reduced the expression and production of inflammatory mediators, including cytokines and matrix metalloproteinase-1/3 in the knee joint tissue and RA synovial fibroblasts, through the downregulation of IKKα/β, ΙκBα, and nuclear factor-κB. Our findings showed that UAA modulated helper T cell immune responses and matrix-degrading enzymes. The effects of UAA were comparable with those of the positive control drug, dexamethasone. In summary, all the evidence presented in this paper suggest that UAA could be a therapeutic candidate for the treatment of RA.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Citation
Jong Yeong Lee et al. (2017). Anti-inflammatory effects of ursolic acid-3-acetate on human synovial fibroblasts and a murine model of rheumatoid arthritis. International Immunopharmacology, 49, 118–125. doi: 10.1016/j.intimp.2017.05.028
Type
Article
ISSN
1567-5769
Source
https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(17)30201-1
DOI
10.1016/j.intimp.2017.05.028
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41073
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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