계명대학교 의학도서관 Repository

Association between Brain-Derived Neurotrophic Factor Gene Polymorphisms and Fibromyalgia in a Korean Population: A Multi-Center Study

Metadata Downloads
Author(s)
Dong-Jin ParkSeong-Ho KimSeong-Su NahJi Hyun LeeSeong-Kyu KimYeon-Ah LeeSeung-Jae HongHyun-Sook KimHye-Soon LeeHyoun Ah KimChung-Il JoungSang-Hyon KimShin-Seok Lee
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Arthritis Research & Therapy
Issued Date
2018
Volume
20
Keyword
FibromyalgiaBrain-derived neurotrophic factorGeneticsPolymorphism
Abstract
Background: Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the
pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid
levels of BDNF. In this study, we explored the association between BDNF gene polymorphisms and FM susceptibility
and the severity of symptoms.
Methods: In total, 409 patients with FM and 423 healthy controls in 10 medical centers were enrolled from the
Korean nationwide FM survey. The alleles and genotypes at 10 positions in the BDNF gene were genotyped.
Results: The allele and genotype frequencies of BDNF rs11030104 differed significantly between the patients with
FM and the controls (P = 0.031). The GG genotype of rs11030104 had a protective effect against FM (P = 0.016), and
the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P = 0.
013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the
two groups, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P = 0.038). Haplotype
analyses implied that some BDNF haplotypes have a protective effect against FM. Finally, several genotypes and
haplotypes of the BDNF gene contributed to specific symptoms of FM.
Conclusions: This study is the first to evaluate the associations between BDNF gene polymorphisms and FM. Our
results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to,
and contribute to the symptoms of, FM.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine (의과대학)
Citation
Dong-Jin Park et al. (2018). Association between Brain-Derived Neurotrophic Factor Gene Polymorphisms and Fibromyalgia in a Korean Population: A Multi-Center Study. Arthritis Research & Therapy, 20, 220–220. doi: 10.1186/s13075-018-1726-5
Type
Article
ISSN
1478-6354
DOI
10.1186/s13075-018-1726-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41081
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.