계명대학교 의학도서관 Repository

Association between Serum Dipeptidyl Peptidase-4 Concentrarion and Obesity-related Factors in Health Screen Examinees

Metadata Downloads
Author(s)
Ji Yeon LeeByoung Kuk JangMin Kyung SongHye Soon KimMi-Kyung Kim
Keimyung Author(s)
Jang, Byoung KukKim, Hye SoonKim, Mi KyungLee, Ji Yeon
Department
Dept. of Internal Medicine (내과학)
Institute for Cancer Research (암연구소)
Journal Title
Journal of Obestiy & Metabolic Syndrome
Issued Date
2017
Volume
26
Issue
3
Keyword
Dipeptidyl peptidase-4, Obesity, Biomarker
Abstract
Background :

Dipeptidyl peptidase-4 (DPP-4) is an aminopeptidase that inhibits the enzymatic degradation of glucagon-like peptide-1, glucose-dependent insulinotropic polypeptides, neuropeptides, and various chemokines. Recent studies reported that serum DPP-4 concentration is correlated with clinical parameters of obesity. However, research on these correlations has never been conducted in Korea. Therefore, we investigated the relationship between serum DPP-4 concentration and various clinical parameters of obesity in the Korean population.

Methods :
Patients who visited the Health Promotion Center at Keimyung University Dongsan Medical Center for a regular medical examination between January 2013 and March 2013 and consented to participate in this study were included. We measured and analyzed parameters of obesity. In addition, serum DPP-4 concentration was determined using an enzyme-linked immunosorbent assay kit.

Results :
Serum DPP-4 concentration was positively correlated with lean body mass, total cholesterol level, and creatinine level. Serum DPP-4 concentration was higher in the obese group than in the normal body mass index (BMI) group. No significant difference in serum DPP-4 concentration was found between the metabolically healthy group and metabolically unhealthy group.

Conclusion :
Serum DPP-4 concentration was higher in the obesity group than in the normal BMI group, which was associated with obesity-related factors.
Keimyung Author(s)(Kor)
장병국
김혜순
김미경
이지연
Publisher
School of Medicine (의과대학)
Citation
Ji Yeon Lee et al. (2017). Association between Serum Dipeptidyl Peptidase-4 Concentrarion and Obesity-related Factors in Health Screen Examinees. Journal of Obestiy & Metabolic Syndrome, 26(3), 188–196. doi: 10.7570/jomes.2017.26.3.188
Type
Article
ISSN
2508-6235
DOI
10.7570/jomes.2017.26.3.188
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41083
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.