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Change in blood pressure variability in patients with acute ischemic stroke and its effect on early neurologic outcome

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Author(s)
Jihoon KangJeong-Ho HongMin Uk JangNack Cheon ChoiJi Sung LeeBeom Joon KimMoon-Ku HanHee-Joon Bae
Keimyung Author(s)
Hong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
PloS One
Issued Date
2017
Volume
12
Issue
12
Abstract
BACKGROUND:

How short-term blood pressure variability (BPV) is affected in the acute stage of ischemic stroke and whether BPV is associated with early neurologic outcomes remains unclear.

METHODS:

Patients who admitted for ischemic stroke within 24 h of symptom onset were consecutively identified between January 2010 and January 2015. BP profiles measured in real-time were summarized into short-term, 24-h time intervals, based on standard deviation (SD) and mean of systolic BP (SBPSD) during the first 3 days. The primary outcome was daily assessment of early neurological deterioration (END). The associations between short-term SBPSD values and the secular trend for primary outcome were examined.

RESULTS:

A total of 2,545 subjects (mean age, 67.1 ± 13.5 years old and median baseline National Institutes of Health Stroke Scale score, 3) arrived at the hospital an average of 6.1 ± 6.6 h after symptom onset. SBPSD values at day 1 (SD#D1), SD#D2, and SD#D3 were 14.4 ± 5.0, 12.5 ± 4.5, and 12.2 ± 4.6 mmHg, respectively. Multivariable analyses showed that SD#D2 was independently associated with onset of END at day 2 (adjusted odds ratio, 1.08; 95% confidence interval, 1.03-1.13), and SD#D3 was independently associated with END#D3 (1.07, 1.01-1.14), with adjustments for predetermined covariates, SBPmean, and interactions with daily SBPSD.

CONCLUSION:

Short-term BPV changed and stabilized from the first day of ischemic stroke. Daily high BPV may be associated with neurological deterioration independent of BPV on the previous day.
Keimyung Author(s)(Kor)
홍정호
Publisher
School of Medicine (의과대학)
Citation
Jihoon Kang et al. (2017). Change in blood pressure variability in patients with acute ischemic stroke and its effect on early neurologic outcome. PloS One, 12(12), e0189216–e0189216. doi: 10.1371/journal.pone.0189216
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0189216
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41106
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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