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Chemical pleurodesis using doxycycline and Viscum album extract

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Author(s)
Kyung Sub SongDongYoon KeumJae Bum Kim
Keimyung Author(s)
Keum, Dong YoonKim, Jae Bum
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Korean Journal of Thoracic and Cardiovascular Surgery
Issued Date
2017
Volume
50
Issue
4
Keyword
DoxycyclinePleurodesisPneumothoraxViscum album
Abstract
BACKGROUND:

In chemical pleurodesis for managing pulmonary air leak, tetracycline derivatives are commonly used, and their effectiveness has been established in many studies. Recently, a Viscum album extract was used in chemical pleurodesis. We compared the effects of V. album with those of a tetracycline derivative (doxycycline) to demonstrate the therapeutic effectiveness of the V. album extract in chemical pleurodesis for managing pulmonary air leak.

METHODS:

Between October 2010 and October 2016, chemical pleurodesis was performed using doxycycline in 40 patients and the V. album extract in 37 patients. Thirty-three patients were in the postoperative state after pulmonary resection, and 44 patients suffered from spontaneous pneumothorax.

RESULTS:

No statistically significant difference in the success rate was observed between the 2 groups (V. album extract and doxycycline). In both groups, chest pain was the most common complication. More patients in the doxycycline group complained of severe chest pain (42.1% vs. 13.5%, p=0.006). In the V. album extract group, 24.3% of the patients required a chest tube to drain the pleural effusion after cessation of the air leak (doxycycline group: 5%, p=0.022). Further, the amount of pleural effusion drained on the day after the last chemical pleurodesis in the V. album extract group was greater than that in the doxycycline group (162.2±170.2 mL vs. 97.0±77.2 mL, p=0.032). All patients were discharged from the hospital without complications after pleural effusion drainage.

CONCLUSION:

Considering that treatment using the V. album extract was less painful, V. album might be a feasible option for chemical pleurodesis. However, pleural effusion should be monitored carefully when using V. album extract for treating patients suffering from air leak.
Keimyung Author(s)(Kor)
금동윤
김재범
Publisher
School of Medicine (의과대학)
Citation
Kyung Sub Song et al. (2017). Chemical pleurodesis using doxycycline and Viscum album extract. Korean Journal of Thoracic and Cardiovascular Surgery, 50(4), 281–286. doi: 10.5090/kjtcs.2017.50.4.281
Type
Article
ISSN
2233-601X
DOI
10.5090/kjtcs.2017.50.4.281
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41115
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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