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Circulating long non-coding RNA TCONS_00016452 is inversely correlated with liver steatosis in patients with non-alcoholic fatty liver disease

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Author(s)
Jung Gil ParkJee Hyun LeeSoo Young ParkHeon Ju LeeWon Young TakYoung Oh KweonSe Young JangYu Rim LeeGyeonghwa KimEunhye LeeHye Won LeeMan-hoon HanJae Min ChunYoung Seok HanKeun Hur
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
대한간학회 춘·추계 학술대회
Issued Date
2018
Volume
2018
Issue
1
Keyword
LncRNA lexisNon-alcoholic fatty liver diseaseLiver steatosis
Abstract
Aims: To evaluate the circulating lncRNA TCONS_00016452 in
patients with non-alcoholic fatty liver disease (NAFLD)
Methods: We analyzed a total of fifty patients who underwent
percutaneous liver biopsy to confirm NASH, which is
reviewed by one pathologist. Expression of circulating lncRNA
TCONS_00016452 in plasma was compared using quantitative real-
time polymerase chain reaction according to pathologic results.
Results: Expression of circulating lncRNA TCONS_00016452
was significantly decreased in patients with severe steatosis
compared to patients with minimal to moderate steatosis
(13.9±16.0 vs 7.4±5.3, P=0.039. As the grade of steatosis
was advanced, circulating lncRNA TCONS_00016452 was decreased
(r-value=-0.29, P=0.004). However, circulating lncRNA
TCONS_00016452 was decreased in patients with significant fibrosis compare to without significant fibrosis (8.3±5.1 vs
17.2±19.6, P=0.040). Conclusions: Circulating lncRNA TCONS_00016452 is inversely
correlated with grade of liver steatosis in patients with NAFLD.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Jung Gil Park et al. (2018). Circulating long non-coding RNA TCONS_00016452 is inversely correlated with liver steatosis in patients with non-alcoholic fatty liver disease. 대한간학회 춘·추계 학술대회, 2018(1), 229–229.
Type
Article
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3620619
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41118
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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