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Clinical features and prognostic factors of early phase of infection in newborn infants with early-onset sepsis

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Author(s)
Se Jin KimGa Eun KimJae Hyun ParkSang Lak LeeChun Soo Kim
Keimyung Author(s)
Lee, Sang LakKim, Chun SooPark, Jae Hyun
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Korean Journal of Pediatrics
Issued Date
2018
Volume
27
Issue
9
Keyword
Early-onset sepsisClinical featuresPrognosisNeonatal intensive care unit
Abstract
Purpose: This study was undertaken to investigate the clinical features and prognostic factors
of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients.
Methods: A retrospective analysis of the medical records was conducted in a NICU of a
university hospital over a 7.5-year period (Jan 2010-Jun 2017).
Results: During the study period, there were 45 (1.2%) episodes of EOS in 3,862 infants.
The most common pathogen responsible for EOS was Streptococcus group B (GBS) in 10
cases (22.2%), followed by E. coli in 9 cases (20%). The frequency of Gram-positive sepsis
was higher in term than in preterm infants, while the rate of Gram-negative infection was higher
in preterm than in term infants (P<0.05). The overall mortality was 37.8% (17 of 45), and 47%
of deaths occurred within the first 3 days of infection. There was a significant difference in
terms of gestational age (26.8 weeks vs. 35.1 weeks) and birth weight (957 g vs. 2,520 g)
between the death and survival groups. In a comparison after adjusting for the difference in
gestational age and birth weight between the two groups, Gram-negative pathogens (OR: 42,
95% CI: 1.4~1281.8) and some clinical findings, such as neutropenia (OR: 46, 95% CI:
1.3~1628.7) and decreased activity (OR: 34, 95% CI: 1.8~633.4), were associated with
fatality.
Conclusion: The common pathogens responsible for EOS in NICU patients are GBS and E.
coli. Infection caused by Gram-negative bacteria, decreased activity in the early phase of
infection, and neutropenia were associated with poor outcomes.
Keimyung Author(s)(Kor)
이상락
김천수
박재현
Publisher
School of Medicine (의과대학)
Citation
Se Jin Kim et al. (2018). Clinical features and prognostic factors of early phase of infection in newborn infants with early-onset sepsis. Korean Journal of Pediatrics, 27(9), 69–69. doi: 10.3345/kjp.2018.06807
Type
Article
ISSN
1738-1061
DOI
10.3345/kjp.2018.06807
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41120
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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