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Clinical significance of systemic chemotherapy after curative resection of metachronous pulmonary metastases from colorectal cancer

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Author(s)
Sungwoo ParkByung Woog KangSoo Jung LeeShinkyo YoonYee Soo ChaeJong Gwang KimKyung Hee LeeSung Ae KohHong Suk SongKeon Uk ParkJin Young KimMi Hwa HeoHun Mo RyooJungmin JoJung Lim LeeSun Ah LeeYoon Young Cho
Keimyung Author(s)
Park, Keon UkKim, Jin YoungHeo, Mi HwaSong, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Chemotherapy and Pharmacology
Issued Date
2017
Volume
80
Issue
1
Keyword
Carcinoembryonic antigenChemotherapyColorectal cancerNeoplasm metastasis
Abstract
PURPOSE:

The use of systemic chemotherapy after resection remains controversial in patients with resectable metachronous pulmonary metastases from colorectal cancer (CRC). This retrospective study compared systemic chemotherapy with observation alone after resection of pulmonary metastases from CRC.

METHODS:

Between 2001 and 2015, 91 patients with metachronous pulmonary metastases underwent curative surgical resection at five centers. Patients with stage IV at diagnosis were excluded. Overall survival (OS) was defined as the time from pulmonary resection until death. The disease-free interval (DFI) was defined as the time from pulmonary resection until recurrence or death.

RESULTS:

Among the 91 patients, 63 were in the chemotherapy group, while 28 were in the observation alone group. The characteristics were similar between the two groups, except for the carcinoembryonic antigen level after pulmonary metastases and the use of adjuvant treatment after resection of the primary tumor. With a median follow-up duration of 46 months (11-126), the estimated 5-year DFI and OS rates were 32.8 and 61.4%, respectively. The chemotherapy following pulmonary resection was not significantly associated with the DFI (p = 0.416) and OS (p = 0.119).

CONCLUSION:

Systemic chemotherapy after pulmonary resection was not found to have a significant effect on survival.
Keimyung Author(s)(Kor)
박건욱
김진영
허미화
송홍석
Publisher
School of Medicine (의과대학)
Citation
Sungwoo Park et al. (2017). Clinical significance of systemic chemotherapy after curative resection of metachronous pulmonary metastases from colorectal cancer. Cancer Chemotherapy and Pharmacology, 80(1), 187–193. doi: 10.1007/s00280-017-3348-z
Type
Article
ISSN
0344-5704
Source
https://link.springer.com/article/10.1007%2Fs00280-017-3348-z
DOI
10.1007/s00280-017-3348-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41129
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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