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Combined intraoperative paracetamol and preoperative dexamethasone reduces postoperative sore throat: a prospective randomized study

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Author(s)
Jiwon LeeHee-Pyoung ParkMu-Hui JeongHyun-Chang Kim
Keimyung Author(s)
Kim, Hyun ChangLee, Ji Won
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Anesthesia
Issued Date
2017
Volume
31
Issue
6
Keyword
AcetaminophenDexamethasoneIntubationPharyngitisPostoperative pain
Abstract
PURPOSE:

Postoperative sore throat (POST) after general anesthesia with endotracheal intubation is a common and undesirable complication. In this study, we evaluated the combined effects of paracetamol and dexamethasone on the prevention of POST in patients after general anesthesia.

METHODS:

A total of 226 patients scheduled for urologic surgery under general anesthesia were randomly assigned to one of two groups. In the DexaPara group (n = 113), dexamethasone (10 mg) and paracetamol (1000 mg) was infused. In the Dexa group (n = 113), dexamethasone (10 mg) alone was given. POST, hoarseness, and dysphagia were monitored. The postoperative wound pain score and perioperative opioid requirements were compared. In addition, complications related to opioids were compared between the groups.

RESULTS:

The overall incidence of POST was lower in the DexaPara group than in the Dexa group [42 (37%) vs. 72 (64%), p < 0.001]. The incidence of POST while resting at postoperative 1 and 6 h was lower in the DexaPara group than in the Dexa group (p = 0.008 and p = 0.004, respectively). The incidence of postoperative nausea, vomiting, drowsiness, shivering, and headache was comparable between the groups.

CONCLUSIONS:

Paracetamol and dexamethasone infusion reduced the incidence of POST without serious complications in patients for urologic surgery under general anesthesia.
Keimyung Author(s)(Kor)
김현창
이지원
Publisher
School of Medicine (의과대학)
Citation
Jiwon Lee et al. (2017). Combined intraoperative paracetamol and preoperative dexamethasone reduces postoperative sore throat: a prospective randomized study. Journal of Anesthesia, 31(6), 869–877. doi: 10.1007/s00540-017-2411-6
Type
Article
ISSN
0913-8668
Source
https://link.springer.com/article/10.1007%2Fs00540-017-2411-6
DOI
10.1007/s00540-017-2411-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41139
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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