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Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells

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Author(s)
Seon Min WooSeung Un SeoKyoung-jin MinSeung-Soon ImJu-Ock NamJong-Soo ChangShin KimJong-Wook ParkTaeg Kyu Kwon
Keimyung Author(s)
Im, Seung SoonKim, ShinPark, Jong WookKwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Dept. of Physiology (생리학)
Journal Title
International Journal of Molecular Sciences
Issued Date
2018
Volume
19
Issue
5
Keyword
corosolic acidlipid ROSnon-apoptotic cell deathα-tocopherol
Abstract
Corosolic acid is one of the pentacyclic triterpenoids isolated from Lagerstroemia speciose and has been reported to exhibit anti-cancer and anti-proliferative activities in various cancer cells. In the present study, we investigated the molecular mechanisms of corosolic acid in cancer cell death. Corosolic acid induces a decrease of cell viability and an increase of cell cytotoxicity in human renal carcinoma Caki cells. Corosolic acid-induced cell death is not inhibited by apoptosis inhibitor (z-VAD-fmk, a pan-caspase inhibitor), necroptosis inhibitor (necrostatin-1), or ferroptosis inhibitors (ferrostatin-1 and deferoxamine (DFO)). Furthermore, corosolic acid significantly induces reactive oxygen species (ROS) levels, but antioxidants (N-acetyl-l-cysteine (NAC) and trolox) do not inhibit corosolic acid-induced cell death. Interestingly, corosolic acid induces lipid oxidation, and α-tocopherol markedly prevents corosolic acid-induced lipid peroxidation and cell death. Anti-chemotherapeutic effects of α-tocopherol are dependent on inhibition of lipid oxidation rather than inhibition of ROS production. In addition, corosolic acid induces non-apoptotic cell death in other renal cancer (ACHN and A498), breast cancer (MDA-MB231), and hepatocellular carcinoma (SK-Hep1 and Huh7) cells, and α-tocopherol markedly inhibits corosolic acid-induced cell death. Therefore, our results suggest that corosolic acid induces non-apoptotic cell death in cancer cells through the increase of lipid peroxidation.
Keimyung Author(s)(Kor)
김신
임승순
박종욱
권택규
Publisher
School of Medicine (의과대학)
Citation
Seon Min Woo et al. (2018). Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells. International Journal of Molecular Sciences, 19(5), e1309–e1309. doi: 10.3390/ijms19051309
Type
Article
ISSN
1422-0067
DOI
10.3390/ijms19051309
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41161
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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