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Development and Validation of Endoscopic Prediction Model for GAstric Cytomegalovirus Infection in Patients with Renal Transplantation

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Author(s)
Seong Jae YeoEun Soo KimMin Kyu JungSung Kook KimHyun Seok LeeLee Joon SeopSang Won LeeYoo Jin LeeSun JinSeung-Yeup Han
Keimyung Author(s)
Lee, Yoo JinKim, Eun SooHan, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Gastroenterology
Issued Date
2018
Volume
154
Issue
6
Abstract
Background and aims: Cytomegalovirus (CMV) is a very common viral pathogen after
organ transplant patients. However, endoscopic characteristics of gastric CMV infection have
not been established. We aimed to develop and validate a prediction model using endoscopic
findings for gastric CMV infection in patients with renal transplantation. Patients and
methods: A retrospective study was performed in a tertiary referral hospital enrolling 354
kidney transplant recipients who received endoscopy with biopsy for suspected CMV infection
from Jan. 2005 to Nov. 2015. For the development phase, endoscopic parameters were
selected by univariate logistic regression analyses. Then, the prediction model was established
on the basis of b coefficients of the multivariate logistic regression. For the validation of the
model, the same regression equation was tested on the other group. Results: Age, days
from renal transplantation to endoscopic biopsy, erosion at antrum, erosion with exudate,
raised erosion, and ulcer at antrum were selected as the predicting factors for gastric CMV
infection. In the development set (n=176) using these five markers, the sensitivity, specificity,
positive predictive value (PPV), and negative predictive value (NPV) were 92.23, 80.82,
87.16, and 88.06, respectively. In the validation set (n=178), the sensitivity, specificity, PPV,
and NPV were 83.87, 82.35, 83.87 and 82.35, respectively. Conclusion: This endoscopic
prediction model using 6 risk factors can be a reliable diagnostic tool for gastric CMV
infection after renal transplantation.
Keimyung Author(s)(Kor)
이유진
김은수
한승엽
Publisher
School of Medicine (의과대학)
Citation
Seong Jae Yeo et al. (2018). Development and Validation of Endoscopic Prediction Model for GAstric Cytomegalovirus Infection in Patients with Renal Transplantation. Gastroenterology, 154(6), S-878. doi: 10.1016/S0016-5085(18)32969-X
Type
Article
ISSN
0016-5085
Source
https://www.sciencedirect.com/science/article/pii/S001650851832969X
DOI
10.1016/S0016-5085(18)32969-X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41177
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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