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Effect and mechanisms of diabetes resolution according to the range of gastric resection and the length of anastomosis in animal models: Implication for gastric cancer surgery in patients with diabetes mellitus

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Author(s)
Yeon-Ju HuhYoung-Gil SonTae-Han KimJi-Ho ParkTae-Jung OhBoram ChoiJimin MinYoung Min ChoHan-Kwang YangHyuk-Joon
Keimyung Author(s)
Son, Young Gil
Department
Dept. of Surgery (외과학)
Journal Title
World Journal of Surgery
Issued Date
2018
Volume
4
Issue
2
Abstract
BACKGROUND:

To examine the effect and mechanism of Roux-en-Y gastric bypass (RYGB) on the improvement of diabetes according to the length of anastomosis and the gastric pouch volume in an animal model.

METHODS:

Glucose intolerance was induced with a high-fat diet for 3 months in Sprague-Dawley rats. The animals were subjected to conventional RYGB (cRYGB; 5% gastric pouch with 15-cm Roux limb, 40-cm biliopancreatic limb; n = 9), short-limb RYGB (sRYGB; 5%, 8, 4 cm; n = 9), fundus-sparing RYGB (fRYGB; 30%, 8, 4 cm; n = 9), or sham operation (n = 9). After 6 weeks, oral glucose tolerance tests (OGTTs) were performed, and gut hormones including insulin, total GLP-1, GIP, and ghrelin were analyzed.

RESULTS:

The cRYGB group showed significantly decreased food intake, body weight, and random glucose (p < 0.05). sRYGB resulted in a similar change of body weight loss to that of cRYGB, but with no improvement of hyperglycemia. The fRYGB group showed similar changes of body weight and random glucose to those of the sham group. In cRYGB and sRYGB, the level of insulin steeply increased until 30 min during OGTT. GLP-1 was higher at 30 min in cRYGB than in other groups, without significance. The fRYGB group showed a slowly increasing pattern in OGTT and GLP-1, and the lowest peak point in insulin and GIP.

CONCLUSION:

cRYGB with 95% gastric resection was needed to achieve not only weight loss but also diabetes improvement, which could be related to the increase in GLP-1.
Keimyung Author(s)(Kor)
손영길
Publisher
School of Medicine (의과대학)
Citation
Yeon-Ju Huh et al. (2018). Effect and mechanisms of diabetes resolution according to the range of gastric resection and the length of anastomosis in animal models: Implication for gastric cancer surgery in patients with diabetes mellitus. World Journal of Surgery, 4(2), 1056–1064. doi: 10.1007/s00268-017-4228-8
Type
Article
ISSN
0364-2313
Source
https://link.springer.com/article/10.1007%2Fs00268-017-4228-8
DOI
10.1007/s00268-017-4228-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41205
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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