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Effect of statin on progression of symptomatic basilar artery stenosis and subsequent ischemic stroke

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Author(s)
Kyu Sun YumJun Young ChangWon Joo JeongSangkil LeeJin-Heon JeongMin-Ju YeoJeong-Ho HongHong-Kyun ParkInyoung ChungBeom Joon KimJae Seung BangHee-Joon BaeMoon-Ku Han
Keimyung Author(s)
Hong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
PloS One
Issued Date
2017
Volume
12
Issue
10
Abstract
BACKGROUND AND OBJECTIVE:

Symptomatic basilar artery stenosis (BAS) is associated with high risk of ischemic stroke recurrence. We aimed to investigate whether statin therapy might prevent the progression of symptomatic BAS and stroke recurrence.

METHODS:

We retrospectively analyzed the data of patients with acute ischemia with symptomatic BAS, which was assessed using magnetic resonance angiogram (MRA) imaging on admission day, and 1 year later (or the day of the clinical event). The clinical endpoints were recurrent ischemic stroke and its composites, transient ischemic attack, coronary disease, and vascular death.

RESULTS:

Of the 153 patients with symptomatic BAS, 114 (74.5%) were treated with a statin after experiencing a stroke. Statin therapy significantly prevented the progression of symptomatic BAS (7.0% vs 28.2%) and induced regression (22.8% vs 15.4%) compared to non-statin users (p = 0.002). There were 31 ischemic stroke incidences and 38 composite vascular events. Statin users showed significantly lower stroke recurrence (14.9% vs 35.9%, p = 0.05) and composite vascular events (17.5% vs 46.2%; odds ratio [OR], 0.29; 95% confidence interval [CI], 0.13-0.64) than those not using statins did. Recurrent stroke in the basilar territory and composite vascular events were more common in patients with progression of BAS than they were in other patients (OR, 5.16; 95% CI, 1.63-16.25 vs OR, 4.2; 95% CI, 1.56-11.34).

CONCLUSION:

Our study suggests that statin therapy may prevent the progression of symptomatic BAS and decrease the risk of subsequent ischemic stroke. Large randomized trials are needed to confirm this result.
Keimyung Author(s)(Kor)
홍정호
Publisher
School of Medicine (의과대학)
Citation
Kyu Sun Yum et al. (2017). Effect of statin on progression of symptomatic basilar artery stenosis and subsequent ischemic stroke. PloS One, 12(10), e0183798–e0183798. doi: 10.1371/journal.pone.0183798
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0183798
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41208
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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