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Effects of preoperative aspirin on perioperative platelet activation and dysfunction in patients undergoing off-pump coronary artery bypass

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Author(s)
Jiwon LeeChul-Woo JungYunseok JeonTae Kyong KimYoun Joung ChoChang-Hoon KooYoon Hyeong ChoiKi-Bong KimHo Young HwangHang-Rae KimJi-Young Park
Keimyung Author(s)
Lee, Ji Won
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
PLoS One
Issued Date
2017
Volume
12
Issue
7
Abstract
The benefit of aspirin use after coronary artery bypass graft surgery has been well proven. However, the effect of preoperative aspirin use in patients undergoing off-pump coronary artery bypass graft surgery (OPCAB) has not been evaluated sufficiently. To evaluate platelet function changes during OPCAB due to preoperative aspirin use, we conducted a randomized controlled trial using flow cytometry and the Multiplate® analyzer. Forty-eight patients scheduled for elective OPCAB were randomized to the aspirin continuation (100 mg/day until operative day) and discontinuation (4 days before the operative day) groups. Platelet function was measured using the platelet activation markers CD62P, CD63, and PAC-1 by flow cytometry, and platelet aggregation was measured using the Multiplate® analyzer, after the induction of anesthesia (baseline), at the end of the operation, and 24 and 48 h postoperatively. Findings of conventional coagulation assays, thromboelastography by ROTEM® assays, and postoperative bleeding-related clinical outcomes were compared between groups. No significant change in CD62P, CD63, or PAC-1 was observed at the end of the operation or 24 or 48 h postoperatively compared with baseline in either group. The area under the curve for arachidonic acid-stimulated platelet aggregation, measured by the Multiplate® analyzer, was significantly smaller in the aspirin continuation group (P < 0.01). However, chest tube drainage and intraoperative and postoperative transfusion requirements did not differ between groups. Our study showed that preoperative use of aspirin for OPCAB did not affect perioperative platelet activation, but it impaired platelet aggregation, which did not affect postoperative bleeding, by arachidonic acid.
Keimyung Author(s)(Kor)
이지원
Publisher
School of Medicine (의과대학)
Citation
Jiwon Lee et al. (2017). Effects of preoperative aspirin on perioperative platelet activation and dysfunction in patients undergoing off-pump coronary artery bypass. PLoS One, 12(7), e0180466–e0180466. doi: 10.1371/journal.pone.0180466
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0180466
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41219
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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