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Effects of vascular formation during alveolar bone process morphogenesis in mice

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Author(s)
Seo-Young AnYe-Ji LeeSanjiv NeupaneJong-Hwa JunJi-Youn KimYoungkyun LeeKarp-Shik ChoiChang-Hyeon AnHong-In ShinWern-Joo SohnJae-Young KimJo-Young Suh
Keimyung Author(s)
Jun, Jong Hwa
Department
Dept. of Ophthalmology (안과학)
Journal Title
Histochemistry and Cell Biology
Issued Date
2017
Volume
148
Issue
4
Keyword
Alveolar bone processBevacizumabMicroinjection modelPeriodontiumVEGF
Abstract
The alveolar bone process is the thickened ridge of bone that bears the teeth and is known to have dynamic functional interactions with surrounding tissues. However, the detailed morphological changes that occur during alveolar bone process development and the underlying molecular mechanisms behind this morphogenesis have not been elucidated. In this study, we examined the detailed morphological changes of the alveolar bone process during mouse development using HE and MTC staining. In addition, we evaluated the precise localization pattern of various signaling molecules involved in blood vessel formation including CD31, α-SMA, VEGF, periostin, and TGF-β. Innervation of the alveolar bone process was examined following injection of the nerve terminal dye AM1-43. The morphological and immunohistochemical data suggested that there is an intimate relationship between alveolar bone process development and blood vessel formation. To more closely examine the role of blood vessels in alveolar bone process formation, we microinjected mice with a clinically available anti-VEGF antibody, bevacizumab, at PN5 and analyzed the effects 5 days later. Compared to the control animals, anti-VEGF treated animals showed a disruption of the integration of bony tissues to form the alveolar bone process structures, which should contain the periodontal ligaments. Based on these data, we conclude that specific morphogenesis of the alveolar bone process is closely associated with blood vessel formation.
Keimyung Author(s)(Kor)
전종화
Publisher
School of Medicine (의과대학)
Citation
Seo-Young An et al. (2017). Effects of vascular formation during alveolar bone process morphogenesis in mice. Histochemistry and Cell Biology, 148(4), 435–443. doi: 10.1007/s00418-017-1584-
Type
Article
ISSN
0948-6143
Source
https://link.springer.com/article/10.1007%2Fs00418-017-1584-2
DOI
10.1007/s00418-017-1584-
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41221
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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