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Effetc of BCAAs on the progression of advanced liver disease a Korean nationwide, multicenter, prospective, observational cohort study

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Author(s)
Jung Gil ParkWon Young TakSoo Young ParkYoung Oh KweonSe Young JangYu Rim LeeSi Hyun BaeJae Young JangDo Young KimJune Sung LeeKi Tae SukIn Hee KimHeon Ju LeeWoo Jin ChungByoung Kuk JangJeong Ill SuhJeong HeoWon Kee Lee
Keimyung Author(s)
Chung, Woo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Medicine
Issued Date
2017
Volume
96
Issue
24
Keyword
branched-chain amino acidcomplicationliver cirrhosisnutritionprognosis
Abstract
Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited.

Patients who were diagnosed with liver cirrhosis with a Child–Pugh (CP) score of 8–10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. We analyzed the improvements based on the model for end-stage liver disease (MELD) score, CP score, incidence of cirrhosis-related complications, and event-free survival over 2 years. Among the 867 recruited patients, 307 (166 in the BCAA group and 141 in the control group) were analyzed. The BCAA group was divided into 3 subgroups, whose patients consumed 4.15 g, 8.3 g, or 12.45 g of BCAAs daily for the analysis. There were significant differences in the CP score, albumin, and hepatic encephalopathy between the 2 groups at baseline. After matching the propensity scores, we analyzed patients in the BCAA-12.45 g group (12.45 g of BCAAs daily, n = 41) and matched control group (n = 41). The MELD score significantly improved in the BCCA-12.45 g group compared to the matched control group (P = .004). The changes in the serum bilirubin level (P = .014) and CP score (P = .033) over time also differed significantly between the 2 groups. The incidence rates of cirrhosis-related complications (P = .973) and development of hepatocellular carcinoma (2 cases each) did not differ significantly between the 2 groups.

Long-term oral BCAA supplementation has beneficial effects in patients with advanced liver cirrhosis. A further large-scale prospective study is needed to delineate these beneficial effects.
Keimyung Author(s)(Kor)
정우진
Publisher
School of Medicine (의과대학)
Citation
Jung Gil Park et al. (2017). Effetc of BCAAs on the progression of advanced liver disease a Korean nationwide, multicenter, prospective, observational cohort study. Medicine, 96(24), e6580–e6580. doi: 10.1097/MD.0000000000006580
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000006580
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41222
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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