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Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation

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Author(s)
Min-Jong KimYeon-Yong KimYoung-Ae ChoiMoon-Chang BaekByungheon LeePil-Hoon ParkTae-Yong ShinTaeg Kyu KwonDongwoo KhangSang-Hyun Kim
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Frontiers in Pharmacology
Issued Date
2018
Volume
9
Keyword
allergic inflammationanaphylaxiselaeocarpusinhistaminemast cells
Abstract
Mast cells are major effector cells for allergic responses that act by releasing inflammatory mediators, such as histamine and pro-inflammatory cytokines. Accordingly, different strategies have been pursued to develop anti-allergic and anti-inflammatory candidates by regulating the function of mast cells. The purpose of this study was to determine the effectiveness of elaeocarpusin (EL) on mast cell-mediated allergic inflammation. We isolated EL from Elaeocarpus sylvestris L. (Elaeocarpaceae), which is known to possess anti-inflammatory properties. For this study, various sources of mast cells and mouse anaphylaxis models were used. EL suppressed the induction of markers for mast cell degranulation, such as histamine and β-hexosaminidase, by reducing intracellular calcium levels. Expression of pro-inflammatory cytokines, such as tumor necrosis factor-α and IL-4, was significantly decreased in activated mast cells by EL. This inhibitory effect was related to inhibition of the phosphorylation of Fyn, Lyn, Syk, and Akt, and the nuclear translocation of nuclear factor-κB. To confirm the effect of EL in vivo, immunoglobulin E-mediated passive cutaneous anaphylaxis (PCA) and ovalbumin-induced active systemic anaphylaxis (ASA) models were induced. EL reduced the PCA reaction in a dose dependent manner. In addition, EL attenuated ASA reactions such as hypothemia, histamine release, and IgE production. Our results suggest that EL is a potential therapeutic candidate for allergic inflammatory diseases that acts via the inhibition of mast cell degranulation and expression of proinflammatory cytokines.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Citation
Min-Jong Kim et al. (2018). Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation. Frontiers in Pharmacology, 9, 591–591. doi: 10.3389/fphar.2018.00591
Type
Article
ISSN
1663-9812
DOI
10.3389/fphar.2018.00591
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41235
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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