계명대학교 의학도서관 Repository

Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children : an IRLSSG task force report

Metadata Downloads
Author(s)
Richard P. AllenDaniel L. PicchiettiMichael AuerbachYong Won ChoJames R. ConnorChristopher J. EarleyDiego Garcia-BorregueroSuresh KotagalMauro ManconiWilliam OndoJan UlfbergJohn W. WinkelmanOn behalf of the International Restless Legs Syndrome Study Group (IRLSSG)
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Sleep Medicine
Issued Date
2018
Volume
41
Keyword
ConsensusGuidelinesIntravenous ironOral ironRestless legs syndromeTreatment
Abstract
BACKGROUND:

Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend iron treatment when peripheral iron levels are low. In order to assess the evidence on the oral and intravenous (IV) iron treatment of RLS and periodic limb movement disorder (PLMD) in adults and children, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies and provide evidence-based and consensus guidelines for the iron treatment of RLS in adults, and RLS and PLMD in children.

METHODS:

A literature search was performed to identify papers appearing in MEDLINE from its inception to July 2016. The following inclusion criteria were used: human research on the treatment of RLS or periodic limb movements (PLM) with iron, sample size of at least five, and published in English. Two task force members independently evaluated each paper and classified the quality of evidence provided.

RESULTS:

A total of 299 papers were identified, of these 31 papers met the inclusion criteria. Four studies in adults were given a Class I rating (one for IV iron sucrose, and three for IV ferric carboxymaltose); only Class IV studies have evaluated iron treatment in children. Ferric carboxymaltose (1000 mg) is effective for treating moderate to severe RLS in those with serum ferritin <300 μg/l and could be used as first-line treatment for RLS in adults. Oral iron (65 mg elemental iron) is possibly effective for treating RLS in those with serum ferritin ≤75 μg/l. There is insufficient evidence to make conclusions on the efficacy of oral iron or IV iron in children.

CONCLUSIONS:

Consensus recommendations based on clinical practice are presented, including when to use oral iron or IV iron, and recommendations on repeated iron treatments. New iron treatment algorithms, based on evidence and consensus opinion have been developed.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine (의과대학)
Citation
Richard P. Allen et al. (2018). Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children : an IRLSSG task force report. Sleep Medicine, 41, 27–44. doi: 10.1016/j.sleep.2017.11.1126
Type
Article
ISSN
1389-9457
DOI
10.1016/j.sleep.2017.11.1126
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41251
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.