계명대학교 의학도서관 Repository

Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013

Metadata Downloads
Author(s)
Ki Wook YunEun Hwa ChoiHoan Jong LeeJin Han KangKyung-Hyo KimDong Soo KimYae-Jean KimByung Wook EunSung Hee OhHye-Kyung ChoYoung Jin HongKwang Nam KimNam Hee KimYun-Kyung KimHyunju LeeTaekjin LeeHwang Min KimEun Young ChoChun Soo KimSu Eun ParkChi Eun OhDae Sun JoYoung Youn ChoiJina Lee
Keimyung Author(s)
Kim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
BMC Infectious Diseases
Issued Date
2018
Volume
18
Issue
1
Keyword
ChildrenInvasive pneumococcal diseasesMultilocus sequence typingPneumococcal conjugate vaccine
Abstract
BACKGROUND:

Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea.

METHODS:

A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995-2003; n = 70), post-PCV7 (2004-2010; n = 142), and post-PCV13 (2011-2013; n = 73) periods.

RESULTS:

Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9 V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%.

CONCLUSION:

The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs.
Keimyung Author(s)(Kor)
김천수
Publisher
School of Medicine (의과대학)
Citation
Ki Wook Yun et al. (2018). Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013. BMC Infectious Diseases, 18(1), 268–268. doi: 10.1186/s12879-018-3177-7
Type
Article
ISSN
1471-2334
DOI
10.1186/s12879-018-3177-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41265
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.