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Impact of preoperative endoscopic cholangiography and biliary drainage in Ampulla of Vater cancer

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Author(s)
Keun Soo AhnKoo Jeong KangYong Hoon KimYoon Suk LeeGwang Bum ChoTae-Seok KimJung Woo Lee
Keimyung Author(s)
Kang, Koo JeongCho, Kwang BumKim, Yong HoonAhn, Keun SooKim, Tae Seok
Department
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Journal Title
Surgical Oncology
Issued Date
2018
Volume
27
Issue
1
Keyword
Ampulla of vaterBiliary drainageEndoscopic retrograde cholangiopancreatographyMalignancy
Abstract
BACKGROUND:

Ampulla of Vater (AOV) carcinoma is a rare malignancy but has a relatively good prognosis. The aims of this study were to determine the clinicopathologic factors associated with survival and disease recurrence in patients with AOV cancer, focusing on the impact of preoperative endoscopic retrograde cholangiopancreatography (ERCP) and type of biliary drainage (endoscopic retrograde biliary drainage [ERBD] or percutaneous transhepatic biliary drainage [PTBD]).

METHODS:

We retrospectively reviewed the medical records of 80 patients who underwent curative resection for AOV cancer at a single institution between 1995 and 2015. The clinicopathologic factors associated with survival and disease recurrence were analyzed using univariate and multivariable tests.

RESULTS:

The 5-year disease-free and overall actuarial survival rates were 39.3% and 51.3%, respectively. Moderate or poor differentiation, preoperative ERCP, advanced T stage, lymph node metastases, advanced stage and lymphovascular invasion were associated with disease-free survival in univariate analyses. The prognosis was worse in patients who underwent ERBD than in patients who underwent PTBD or no biliary drainage. Multivariable analysis showed that advanced AJCC stage and preoperative ERCP were independent risk factors for recurrence. Patient who underwent preoperative ERCP had a significantly higher rate of early distant metastasis within 1 year, especially in patients with early stage AOV cancer.

CONCLUSIONS:

Preoperative ERCP was an independent risk factor for postoperative recurrence in patients with AOV cancer, and is characterized by early distant metastasis in early stage cancer. Therefore, unnecessary ERCP should be avoided in patients with AOV cancer. If biliary drainage is necessary, PTBD may be preferred to ERBD in AOV cancer.
Keimyung Author(s)(Kor)
김용훈
안근수
강구정
김태석
조광범
Publisher
School of Medicine (의과대학)
Citation
Keun Soo Ahn et al. (2018). Impact of preoperative endoscopic cholangiography and biliary drainage in Ampulla of Vater cancer. Surgical Oncology, 27(1), 82–87. doi: 10.1016/j.suronc.2017.12.002
Type
Article
ISSN
0960-7404
Source
https://linkinghub.elsevier.com/retrieve/pii/S0960-7404(17)30325-0
DOI
10.1016/j.suronc.2017.12.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41291
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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