계명대학교 의학도서관 Repository

Induction of inflammation in vitro by electrocardiogram sensor operation using wireless power transmission

Metadata Downloads
Author(s)
Jin-Chul HeoBeomjoon KimYoon-Nyun KimDae-Kwang KimJong-Ha Lee
Keimyung Author(s)
Lee, Jong HaKim, Dae KwangKim, Yoon Nyun
Department
Dept. of Biomedical Engineering (의용공학과)
Dept. of Medical Education (의학교육학)
Dept. of Internal Medicine (내과학)
Journal Title
Sensors
Issued Date
2017
Volume
17
Issue
12
Keyword
biocompatibilityelectrocardiogramimplantable sensorwireless power
Abstract
Prolonged monitoring by cardiac electrocardiogram (ECG) sensors is useful for patients with emergency heart conditions. However, implant monitoring systems are limited by lack of tissue biocompatibility. Here, we developed an implantable ECG sensor for real-time monitoring of ventricular fibrillation and evaluated its biocompatibility using an animal model. The implantable sensor comprised transplant sensors with two electrodes, a wireless power transmission system, and a monitoring system. The sensor was inserted into the subcutaneous tissue of the abdominal area and operated for 1 h/day for 5 days using a wireless power system. Importantly, the sensor was encapsulated by subcutaneous tissue and induced angiogenesis, inflammation, and phagocytosis. In addition, we observed that the levels of inflammation-related markers increased with wireless-powered transmission via the ECG sensor; in particular, levels of the Th-1 cytokine interleukin-12 were significantly increased. The results showed that induced tissue damage was associated with the use of wireless-powered sensors. We also investigated research strategies for the prevention of adverse effects caused by lack of tissue biocompatibility of a wireless-powered ECG monitoring system and provided information on the clinical applications of inflammatory reactions in implant treatment using the wireless-powered transmission system.
Keimyung Author(s)(Kor)
김대광
김윤년
이종하
Publisher
School of Medicine (의과대학)
Citation
Jin-Chul Heo et al. (2017). Induction of inflammation in vitro by electrocardiogram sensor operation using wireless power transmission. Sensors, 17(12), 2905–2905. doi: 10.3390/s17122905
Type
Article
ISSN
1424-8220
DOI
10.3390/s17122905
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41304
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.