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Intrathecal morphine for postoperative pain control following robot‑assisted prostatectomy: a prospective randomized trial

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Author(s)
Junyeol BaeHyun-Chang KimDeok Man Hong
Keimyung Author(s)
Kim, Hyun Chang
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of Anesthesia
Issued Date
2017
Volume
31
Issue
4
Keyword
InjectionsSpinalMorphineProstatectomyPainPostoperative
Abstract
Purpose :

Robot-assisted laparoscopic prostatectomy (RALP) is minimally invasive surgery, but also causes moderate to severe pain during the immediate postoperative period. We evaluated the efficacy and safety of intrathecal morphine (ITM) for postoperative pain control in patients undergoing RALP.


Methods :
Thirty patients scheduled for RALP were randomly assigned into one of two groups. In the ITM group (n = 15), postoperative pain was managed using 300 µg intrathecal morphine with intravenous patient-controlled analgesia (IV-PCA). In the IV-PCA group (n = 15), only intravenous patient-controlled analgesia was used. The numerical pain score (NPS; 0 = no pain, 100 = worst pain imaginable), postoperative IV-PCA requirements and opioid-related complications including nausea, vomiting, dizziness, headache and pruritus were compared between the two groups.


Results :
The NPSs on coughing were 20 (IQR 10–50) in the ITM group and 60 (IQR 40–80) in the IV-PCA group at postoperative 24 h (p = 0.001). The NPSs were significantly lower in the ITM group up to postoperative 24 h. The ITM group showed less morphine consumption at postoperative 24 h in the ITM group than in the IV-PCA group [5 (IQR 3–15) mg vs 17 (IQR 11–24) mg, p = 0.001]. Complications associated with morphine were comparable between the two groups and respiratory depression was not reported in either group.


Conclusion :
Intrathecal morphine provided more satisfactory analgesia without serious complications during the early postoperative period in patients undergoing RALP.
Keimyung Author(s)(Kor)
김현창
Publisher
School of Medicine (의과대학)
Citation
Junyeol Bae et al. (2017). Intrathecal morphine for postoperative pain control following robot‑assisted prostatectomy: a prospective randomized trial. Journal of Anesthesia, 31(4), 565–571. doi: 10.1007/s00540-017-2356-9
Type
Article
ISSN
0913-8668
Source
https://link.springer.com/article/10.1007%2Fs00540-017-2356-9
DOI
10.1007/s00540-017-2356-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41319
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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