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Korean OBEsity Surgical Treatment Study (KOBESS): protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

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Author(s)
Young Suk ParkDo Joong ParkJoo Ho LeeHyuk-Joon LeeTae Kyung HaYong-Jin KimSeung-Wan RyuSang-Moon HanMoon-Won YooSungsoo ParkSang-Uk HanYoonseok Heo
Keimyung Author(s)
Ryu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
BMJ Open
Issued Date
2017
Volume
7
Issue
10
Keyword
koreamorbid obesityroux-en-y gastric bypasssleeve gastrectomy
Abstract
INTRODUCTION:

Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery.

METHODS AND ANALYSIS:

The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea. In total, 100 consecutive obese Asian patients who will undergo bariatric surgery will be recruited in 2016-2017; follow-up will be for 1 year. Primary outcomes are change in body weight and waist circumference at 1 year. All patients will undergo anthropometry, laboratory tests, bioelectrical impedance analysis, gastrofibroscopy, polysomnography and fat-measuring CT before and after surgery. Patients with diabetes will also undergo perioperative oral glucose tolerance and endocrinological hormone tests. Hypertensive patients will also undergo perioperative echocardiography and carotid Doppler ultrasonography. Female patients suspected of having polycystic ovarian syndrome will also undergo perioperative hormone tests and abdominal ultrasonography. Visceral and subcutaneous fat will be harvested during surgery. Blood, stool and urine samples will be taken at various perioperative time points. Although the cohort is small and the follow-up duration is relatively short, this study will determine whether bariatric surgery induces satisfactory weight loss in obese Koreans. Significantly, the tissue samples will also facilitate many studies examining the effects of bariatric surgery and their mechanisms.

ETHICS AND DISSEMINATION:

Ethics approval was obtained from the institutional review board of each participating hospital. All findings arising from this cohort study will be published in open-access peer-reviewed journals and will be presented at national and international meetings. All KOBESS investigators will be able to propose research studies and potential publications based on KOBESS data and tissue samples.
Keimyung Author(s)(Kor)
류승완
Publisher
School of Medicine (의과대학)
Citation
Young Suk Park et al. (2017). Korean OBEsity Surgical Treatment Study (KOBESS): protocol of a prospective multicentre cohort study on obese patients undergoing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. BMJ Open, 7(10), e018044–e018044. doi: 10.1136/bmjopen-2017-018044
Type
Article
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-018044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41327
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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