계명대학교 의학도서관 Repository

Liver receptor homolog-1 regulates mouse superoxide dismutase 2

Metadata Downloads
Author(s)
Jun-Su LeeSijeong BaeHye-Suk KangSeung-Soon ImYoung-AhMoon
Keimyung Author(s)
Im, Seung Soon
Department
Dept. of Physiology (생리학)
Journal Title
Biochemical and Biophysical Research Communications
Issued Date
2017
Volume
489
Issue
3
Keyword
Liver receptor homolog-1Nonalcoholic fatty liver diseaseReactive oxygen speciesSuperoxide dismutase 2
Abstract
Liver receptor homolog-1 (LRH-1) is a nuclear receptor that plays an important role in the regulation of bile acid biosynthesis, cholesterol reverse transport, steroidogenesis, and exocrine pancreatic enzyme production. In the current study, previously published data from a genome wide analysis of LRH-1 binding in the liver were re-analyzed to identify new LRH-1 targets and propose new roles for LRH-1 in the liver. Superoxide dismutase 2 (Sod2) was identified, which contains putative LRH-1 binding sites in the proximal promoter. When hepatocytes were treated with the LRH-1 agonist RJW101, Sod2 expression was dramatically increased and reactive oxygen species (ROS) production, which was induced by a high concentration of palmitate, was significantly reduced. A LRH-1 binding site was mapped to -288/-283 in the Sod2 promoter, which increased Sod2 promoter activity in response to LRH-1 and its agonist. LRH-1 binding to this site was confirmed using a chromatin immunoprecipitation assay. These results suggest that Sod2 is a target gene of LRH-1, and that LRH-1 agonists can mediate a reduction in ROS production and oxidative stress driven by an excess of fatty acids, as exhibited in nonalcoholic fatty liver disease.
Keimyung Author(s)(Kor)
임승순
Publisher
School of Medicine (의과대학)
Citation
Jun-Su Lee et al. (2017). Liver receptor homolog-1 regulates mouse superoxide dismutase 2. Biochemical and Biophysical Research Communications, 489(3), 299–304. doi: 10.1016/j.bbrc.2017.05.144
Type
Article
ISSN
0006-291X
Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X17310446
DOI
10.1016/j.bbrc.2017.05.144
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41334
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.