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Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model

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Author(s)
Nan Hee KimJin Seong HyeonNam Hoon KimAhreum ChoGayoung LeeSeo Young JangMi-Kyung KimEun Young LeeChoon Hee ChungHunjoo HaGeum Sook Hwang
Keimyung Author(s)
Kim, Mi Kyung
Department
Dept. of Internal Medicine (내과학)
Journal Title
Molecular Cell Biology Research Communications
Issued Date
2018
Volume
646
Keyword
Diabetic kidney diseaseMetabolite profilingNMRProgressiondb/db mice
Abstract
Diabetic kidney disease (DKD) involves various pathogenic processes during progression to end stage renal disease, and activated metabolic pathways might be changing based on major pathophysiologic mechanisms as DKD progresses. In this study, nuclear magnetic resonance spectroscopy (NMR)-based metabolic profiling was performed in db/db mice to suggest potential biomarkers for early detection and its progression. We compared concentrations of serum and urinary metabolites between db/m and db/db mice at 8 or 20 weeks of age and investigated whether changes between 8 and 20 weeks in each group were significant. The metabolic profiles demonstrated significantly increased urine levels of glucose and tricarboxylic acid cycle intermediates at both 8 and 20 weeks of age in db/db mice. These intermediates also exhibited strong positive associations with urinary albumin excretion, suggesting that they may be potential biomarkers for early diagnosis. On the contrary, branched chain amino acid and homocysteine-methionine metabolism were activated early in the disease, whereas ketone and fatty acid metabolism were significantly changed in the late phase of the disease. We demonstrated phase-specific alterations in metabolites during progression of DKD. This study provides insights into perturbed mechanisms during evolution of the disease and identifies potential novel biomarkers for DKD.
Keimyung Author(s)(Kor)
김미경
Publisher
School of Medicine (의과대학)
Citation
Nan Hee Kim et al. (2018). Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model. Molecular Cell Biology Research Communications, 646, 90–97. doi: 10.1016/j.abb.2018.03.042
Type
Article
ISSN
0003-9861
Source
https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(17)30663-X
DOI
10.1016/j.abb.2018.03.042
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41349
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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