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miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma

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Author(s)
SHIN KIMMEI LING SONGHYEONJI MINILSEON HWANGSEONG KYU BAEKTAEG KYU KWONJONG-WOOK PARK
Keimyung Author(s)
Park, Jong WookKwon, Taeg KyuKim, ShinHwang, Il SeonBaek, Seong Kyu
Department
Dept. of Immunology (면역학)
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Institute for Medical Science (의과학연구소)
Journal Title
Oncology Letters
Issued Date
2017
Volume
14
Issue
4
Keyword
DicerDroshacolorectal adenocarcinomamicroRNA biogenesis
Abstract
Drosha and Dicer are important regulators of microRNA (miRNA) biogenesis, and it has been suggested that their aberrant regulation may cause colorectal cancer (CRC). The aim of the present study was to evaluate the mRNA expression levels of these two important RNase III nucleases and their association with clinical features in CRC specimens from South Korean patients. The expression levels of Drosha and Dicer mRNA were investigated in 77 CRC tissues and adjacent histologically non-neoplastic tissues using the quantitative polymerase chain reaction. The expression levels of Drosha and Dicer mRNA were identified to be upregulated in CRC. Neither the Drosha nor the Dicer mRNA expression level was associated with any clinical parameter, including sex, age, TNM stage, body mass index and carcinoembryonic antigen titer in patients with CRC. Furthermore, the expression levels of Drosha and Dicer mRNA were not associated with each other. The miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are significantly upregulated in CRC, suggesting their importance in the pathobiology of colorectal carcinogenesis.
Keimyung Author(s)(Kor)
박종욱
권택규
김신
황일선
백성규
Publisher
School of Medicine (의과대학)
Citation
SHIN KIM et al. (2017). miRNA biogenesis-associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma. Oncology Letters, 14(4), 4379–4383. doi: 10.3892/ol.2017.6674
Type
Article
ISSN
1792-1074
DOI
10.3892/ol.2017.6674
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41356
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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