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Mutation of the TERT promoter leads to poor prognosis of patients with non-small cell lung cancer

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Author(s)
SOO-JUNG JUNGDONG-SUN KIMWON-JIN PARKHYUNSU LEEIN-JANG CHOIJAE-YONG PARKJAE-HO LEE
Keimyung Author(s)
Choi, In JangLee, Jae HoLee, Hyun Su
Department
Dept. of Anatomy (해부학)
Journal Title
Oncology Letters
Issued Date
2017
Volume
14
Issue
2
Keyword
non-small cell lung cancertelomerase reverse transcriptase promoter mutationtelomere length
Abstract
Mutations in the promoter region of telomerase reverse transcriptase (TERT) and alterations in telomere length (TL) have been the focus of research in various types of cancer. In the present study, the frequency and clinical characteristics of TERT promoter mutations and TL were studied in non-small cell lung cancers (NSCLC). TERT promoter mutations and TL were analyzed in 188 patients using DNA sequencing and the reverse transcription-quantitative polymerase chain reaction, respectively. The TERT promoter mutation rate was observed to be 2.2% (4/188 NSCLC cases), and it was significantly associated with regional lymph node invasion (P<0.001). No significant difference in TL was observed between the patients with and without TERT promoter mutations. TL was decreased in males (P=0.058 vs. females) and smokers (P=0.008 vs. non-smokers). Survival analyses demonstrated poor prognoses for patients with NSCLC with TERT promoter mutations (P<0.001). Multivariate survival analyses demonstrated that TERT promoter mutations were an independent prognostic marker for poor overall survival (P=0.045). The results of the present study demonstrated that TERT promoter mutation was not frequent in NSCLC; however, it may have value as a prognostic marker in NSCLC.
Keimyung Author(s)(Kor)
최인장
이재호
이현수
Publisher
School of Medicine (의과대학)
Citation
SOO-JUNG JUNG et al. (2017). Mutation of the TERT promoter leads to poor prognosis of patients with non-small cell lung cancer. Oncology Letters, 14(2), 1609–1614. doi: 10.3892/ol.2017.6284
Type
Article
ISSN
1792-1074
DOI
10.3892/ol.2017.6284
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41362
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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