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Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation

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Author(s)
Kyung Sik ParkSam Ryong JeeBong Eun LeeKyoung Sup HongJeong Eun ShinSoo-Young NaJoong Goo KwonSuck Chei ChoiYong Sung KimHyun Seok LeeTae Hee LeeKyeong Ok KimJongkyoung ChoiHee Seok MoonYeon Soo KimMoo In ParkSoo Jung ParkSeon-Young ParkSung Noh Hong
Keimyung Author(s)
Park, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Neurogastroenterology and Motility
Issued Date
2017
Volume
23
Issue
4
Keyword
ConstipationDyspepsiaGastroesophageal refluxOverlapping
Abstract
BACKGROUND/AIMS:
In spite of increased concerns about the overlaps among the various functional gastrointestinal disorders (FGIDs), studies for the overlap between constipation and other common FGIDs are rare. Therefore, we investigated the patterns of overlaps between constipation and other common FGIDs.

METHODS:
This study was designed as a prospective nationwide multi-center questionnaire study using Rome III questionnaires for functional dyspepsia (FD), irritable bowel syndrome (IBS), and functional constipation (FC), as well as various questionnaires about patients' information, degree of symptoms, and quality of life. For the evaluation of gastroesophageal reflux disease (GERD), GERD-Q was used.

RESULTS:
From 19 centers, 759 patients with constipation were enrolled. The proportions of FC and IBS subtypes of constipation (IBS-C) were 59.4% and 40.6%, respectively. Among them, 492 (64.8%) showed no overlap. One hundred and thirty-six patients (17.9%) presented overlapping GERD, and 80 patients (10.5%) presented overlapping FD. Fifty one (6.7%) of patients were overlapped by both GERD and FD. Coincidental herniated nucleus pulposus (HNP) (P = 0.026) or pulmonary diseases (P = 0.034), reduced fiber intake (P = 0.013), and laxative use (P < 0.001) independently affected the rate of overlaps. These overlapping conditions negatively affected the constipation-associated quality of life, general quality of life, and degree of constipation.

CONCLUSIONS:
The overlap of GERD or FD was common in patients with constipation. Coincidental HNP or pulmonary diseases, reduced fiber intake, and laxatives use were found to be independent associated factors for overlapping common FGIDs in Korean patients with constipation.
Keimyung Author(s)(Kor)
박경식
Publisher
School of Medicine (의과대학)
Citation
Kyung Sik Park et al. (2017). Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation. Journal of Neurogastroenterology and Motility, 23(4), 569–577. doi: 10.5056/jnm17033
Type
Article
ISSN
2093-0879
DOI
10.5056/jnm17033
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41364
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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