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Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease

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Author(s)
Seong Jae YeoHyun Seok LeeByung Ik JangEun Soo KimSeong Woo JeonSung Kook KimKyeong Ok KimYoo Jin LeeHyun Jik LeeKyung Sik ParkYun Jin JungEun Young KimChang Heon YangCrohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Keimyung Author(s)
Lee, Yoo JinPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Intestinal Research
Issued Date
2018
Volume
16
Issue
3
Keyword
Colitis, ulcerativeCrohn diseaseHepatitis B virusInflammatory bowel diseaseVaccination
Abstract
Background/Aims:

This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD).

Methods:

We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls.

Results:

The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged <20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of <20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection.

Conclusions:

The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged <20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD.
Keimyung Author(s)(Kor)
이유진
박경식
Publisher
School of Medicine (의과대학)
Citation
Seong Jae Yeo et al. (2018). Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease. Intestinal Research, 16(3), 400–408. doi: 10.5217/ir.2018.16.3.400
Type
Article
ISSN
1598-9100
DOI
10.5217/ir.2018.16.3.400
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41368
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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