계명대학교 의학도서관 Repository

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels

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Author(s)
Soomin ChaeHyun-Kyung LeeYoo-Kyung KimHyo Jung SimYoorim JiChowon KimTayaba IsmailJeen-Woo ParkOh-Shin KwonBeom-Sik KangDong-Seok LeeJong-Sup BaeSang-Hyun KimKyoung-Jin MinTaeg Kyu KwonMae-Ja ParkJin-Kwan HanTaejoon KwonTae-Joo ParkHyun-Shik Lee
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Scientific Reports
Issued Date
2017
Volume
7
Issue
1
Abstract
Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes. Prdx1 also participates in various age-related diseases and cancers. In this study, we investigated the role of Prdx1 in pronephros development during embryogenesis. Prdx1 knockdown markedly inhibited proximal tubule formation in the pronephros and significantly increased the cellular levels of reactive oxygen species (ROS), which impaired primary cilia formation. Additionally, treatment with ROS (H2O2) severely disrupted proximal tubule formation, whereas Prdx1 overexpression reversed the ROS-mediated inhibition in proximal tubule formation. Epistatic analysis revealed that Prdx1 has a crucial role in retinoic acid and Wnt signaling pathways during pronephrogenesis. In conclusion, Prdx1 facilitates proximal tubule formation during pronephrogenesis by regulating ROS levels.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Citation
Soomin Chae et al. (2017). Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels. Scientific Reports, 7(1), 8874–8874. doi: 10.1038/s41598-017-09262-6
Type
Article
ISSN
2045-2322
DOI
10.1038/s41598-017-09262-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41384
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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