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Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers

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Author(s)
Seoyoung KimJunhyung KimJaehoon ChoiWoonhyeok JeongSunyoung Kwon
Keimyung Author(s)
Kwon, Sun YoungKim, Jun HyungChoi, Jae Hoon
Department
Dept. of Pathology (병리학)
Dept. of Plastic Surgery (성형외과학)
Journal Title
Archives of Plastic Surgery
Issued Date
2017
Volume
44
Issue
6
Keyword
Angiogenesis modulating agentsBlood Gas Monitoring, transcutaneousFoot ulcerPolydeoxyribonucleotides
Abstract
BACKGROUND:

Polydeoxyribonucleotide (PDRN) is known to have anti-inflammatory and angiogenic effects and to accelerate wound healing. The aim of this study was to investigate whether PDRN could improve peripheral tissue oxygenation and angiogenesis in diabetic foot ulcers.

METHODS:

This was a prospective randomized controlled clinical trial. Twenty patients with a non-healing diabetic foot ulcer were randomly distributed into a control group (n=10) and a PDRN group (n=10). Initial surgical debridement and secondary surgical procedures such as a split-thickness skin graft, primary closure, or local flap were performed. Between the initial surgical debridement and secondary surgical procedures, 0.9% normal saline (3 mL) or PDRN was injected for 2 weeks by the intramuscular (1 ampule, 3 mL, 5.625 mg, 5 days per week) and perilesional routes (1 ampule, 3 mL, 5.625 mg, 2 days per week). Transcutaneous oxygen tension (TcPO2) was evaluated using the Periflux System 5000 with TcPO2/CO2 unit 5040 before the injections and on days 1, 3, 7, 14, and 28 after the start of the injections. A pathologic review (hematoxylin and eosin stain) of the debrided specimens was conducted by a pathologist, and vessel density (average number of vessels per visual field) was calculated.

RESULTS:

Compared with the control group, the PDRN-treated group showed improvements in peripheral tissue oxygenation on day 7 (P<0.01), day 14 (P<0.001), and day 28 (P<0.001). The pathologic review of the specimens from the PDRN group showed increased angiogenesis and improved inflammation compared with the control group. No statistically significant difference was found between the control group and the PDRN group in terms of vessel density (P=0.094). Complete healing was achieved in every patient.

CONCLUSIONS:

In this study, PDRN improved peripheral tissue oxygenation. Moreover, PDRN is thought to be effective in improving inflammation and angiogenesis in diabetic foot ulcers.
Keimyung Author(s)(Kor)
권선영
김준형
최재훈
Publisher
School of Medicine (의과대학)
Citation
Seoyoung Kim et al. (2017). Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers. Archives of Plastic Surgery, 44(6), 482–489. doi: 10.5999/aps.2017.00801
Type
Article
ISSN
2234-6163
DOI
10.5999/aps.2017.00801
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41389
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
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