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Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme

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Author(s)
DA EUN JEONGSEON RANG WOOHYUN NAMDO‑HYUN NAMJAE‑HO LEEKYEUNG MIN JOO
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Oncology Letters
Issued Date
2017
Volume
14
Issue
6
Keyword
glioblastoma multiformeself-renewal capacitysphere formationtelomerase reverse transcriptasetelomerase reverse transcriptase promoter mutation
Abstract
The promoter region of the telomerase reverse transcriptase gene (TERT) is mutated in a subpopulation of patients with glioblastoma multiforme (GBM). In the present study, preclinical and clinical implications of the mutation were analyzed in 25 GBMs to evaluate its utility as a therapeutic target. Associations between the TERT promoter mutation and a number of preclinical/clinical characteristics were analyzed. Notably, the TERT promoter mutation was identified in 92.3% of GBMs where dissociated cells revealed in vitro sphere formation capacity; while the TERT promoter mutation was identified in 33.3% of GBMs without in vitro sphere formation capacity (P=0.004). In addition, this significantly increased mutation rate was observed in GBMs with in vivo tumorigenic potential (80% vs. 0%; P=0.004). Furthermore, patients with GBM exhibiting the TERT promoter mutation demonstrated significantly decreased overall survival rate compared with patients lacking this mutation (81.7 vs. 152.6 weeks; P=0.026). The results of the present study indicated that the TERT promoter mutation is associated with the self-renewal capacity of GBM cells and clinical aggressiveness of GBMs, which may be translated to a targeting therapy against TERT to inhibit the self-renewal of GBM cells.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
DA EUN JEONG et al. (2017). Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme. Oncology Letters, 14(6), 8213–8219. doi: 10.3892/ol.2017.7196
Type
Article
ISSN
1792-1074
DOI
10.3892/ol.2017.7196
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41400
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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