계명대학교 의학도서관 Repository

Prevalence and Clinical Characteristics of Local Allergic Rhinitis to House Dust Mites

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Author(s)
Yoo Seob ShinChang-Gyu JungHae-Sim Park
Keimyung Author(s)
Jung, Chang Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Current Opinion in Allergy and Clinical Immunology
Issued Date
2018
Volume
18
Issue
1
Keyword
diagnosisallergenlocal allergic rhinitisprevalencemorbidity
Abstract
PURPOSE OF REVIEW:

Local allergic rhinitis (LAR) is a recently classified subtype of rhinitis defined by a nasal allergic response in patients without systemic evidence of atopy. Recent studies have reported the prevalence, clinical course, culprit allergens, diagnostic methods and treatment outcomes of LAR. The purpose of this review is to summarize the most relevant and updated scientific evidence for LAR, especially focusing on its prevalence and clinical characteristics.

RECENT FINDINGS:

LAR is found in a significant proportion (3.7-61.9%) of patients previously diagnosed with nonallergic rhinitis, but the prevalence may differ among ethnic groups and countries. Common allergens of LAR are similar to those of allergic rhinitis, in which house dust mites are the most common cause, followed by grass pollen, tree pollen, weed pollen and animal dander confirmed by provocation tests. Although the nasal provocation test to a single allergen is considered the gold standard method, the detection of allergen-specific IgE and other inflammatory mediators from nasal secretions and the basophil activation test can assist in the diagnosis of LAR. Conjunctivitis and asthma are the most common comorbid conditions, and the occurrence rate of asthma increases over period. However, the conversion rate to allergic rhinitis was not significantly different between LAR and healthy controls.

SUMMARY:

LAR is a well-differentiated entity of rhinitis, which should be considered in patients with persistent and severe symptoms without any systemic evidence of atopy. Further research is needed to investigate the long-term outcome, and geographic and ethnic differences of LAR.
Keimyung Author(s)(Kor)
정창규
Publisher
School of Medicine (의과대학)
Citation
Yoo Seob Shin et al. (2018). Prevalence and Clinical Characteristics of Local Allergic Rhinitis to House Dust Mites. Current Opinion in Allergy and Clinical Immunology, 18(1), 10–15. doi: 10.1097/ACI.0000000000000413
Type
Article
ISSN
1528-4050
Source
http://insights.ovid.com/pubmed?pmid=29135514
DOI
10.1097/ACI.0000000000000413
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41411
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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