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Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study

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Author(s)
Haeyoung KimWon ParkJeong Il YuDoo Ho ChoiSeung Jae HuhYeon-Joo KimEun Sook LeeKeun Seok LeeHan-Sung KangIn Hae ParkKyung Hwan ShinChan Woo WeeKyubo KimKyung Ran ParkYong Bae KimSung Ja AhnJong Hoon LeeJin Hee KimMison ChunHyung-Sik LeeJung Soo KimJihye Cha
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Cancer Research and Treatment
Issued Date
2017
Volume
49
Issue
4
Keyword
Adjuvant radiotherapyBreast neoplasmsCase-control studiesLymphatic irradiationTaxane
Abstract
PURPOSE:

This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy.

MATERIALS AND METHODS:

We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups.

RESULTS:

A total of 41 patients (7.6%) were found to have recurrence. Supraclavicular lymph node (SCN) failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% versus 92.6% (p=0.50) and 95.1% versus 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI.

CONCLUSION:

We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Haeyoung Kim et al. (2017). Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study. Cancer Research and Treatment, 49(4), 970–980. doi: 10.4143/crt.2016.382
Type
Article
ISSN
1598-2998
DOI
10.4143/crt.2016.382
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41418
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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