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Prognostic impact of telomeric repeat containing RNA expressing on long-term oncologic outcomes in colorectal cancer

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Author(s)
SungUk BaeWoon Kyung JeongSeong Kyu BaeJae-Ho Lee
Keimyung Author(s)
Bae, Sung UkLee, Jae HoBaek, Seong KyuJeong, Woon Kyung
Department
Dept. of Surgery (외과학)
Dept. of Anatomy (해부학)
Journal Title
American Association for Cancer Research
Issued Date
2018
Volume
AACR Annual Meeting 2018
Abstract
Purpose: Telomere shortening is associated with colorectal carcinogenesis and transcription from subtelomeres produces telomeric repeat containing RNA (TERRA), a natural inhibitor of telomerase activity (TA). Previous studies on TERRA expression demonstrated downregulation in advanced stages of human tumors.

Materials and Methods: We evaluated the 2p TERRA expression and telomere length using quantitative real-time PCR in 60 patients who underwent surgical resection for colorectal cancer between June 2008 and November 2010.

Results: Patients were grouped according to 2p TERRA expression, with 27 (45%) and 33 (55%) in the low and high TERRA expression groups, respectively. The median follow-up period was 80 months (range 2-103). 2p TERRA expression was marginally significantly associated with preoperative CEA (P = 0.082) and significantly associated with telomere length (P < 0.05). Five-year overall survival rates in the high 2p TERRA expression group and the low expression group were 73.6% and 78.2%, respectively (p = 0.322), and five-year disease-free survival rates in the high 2p TERRA expression group and the low expression group were 66.1% and 75.1%, respectively (p = 0.317).

Conclusions: 2p TERRA expression was marginally significantly associated with preoperative CEA and significantly associated with telomere length; however, it was not prognostic on long-term oncologic outcomes in colorectal cancer.
Keimyung Author(s)(Kor)
배성욱
이재호
백성규
정운경
Publisher
School of Medicine (의과대학)
Citation
SungUk Bae et al. (2018). Prognostic impact of telomeric repeat containing RNA expressing on long-term oncologic outcomes in colorectal cancer. American Association for Cancer Research, AACR Annual Meeting 2018, 0008–5472. doi: 10.1158/1538-7445.AM2018-2461
Type
Article
ISSN
0099-7374
Source
http://cancerres.aacrjournals.org/content/78/13_Supplement/2461
DOI
10.1158/1538-7445.AM2018-2461
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41420
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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