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Rheumatoid Factor May Associated with Disability in Neuromyelitis Optica Spectrum Disorder

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Author(s)
Hye Lim LeeJu-Hong MinJin Myoung SeokEun Bin ChoHo Jin KimHa Young ShinByung Jo KimSeol-Hee BaekHung Youl SeokSa-Yoon KangOh-Hyun KwonKwang-Kuk KimYoung-Min LimSang-Soo LeeJeeyoung OhSo-Young HuhJong Kuk KimByeol-A YoonEun-Hee SohnJoong-Yang ChoHye jin ChoByoung Joon Kim
Keimyung Author(s)
Seok, Hung Youl
Department
Dept. of Neurology (신경과학)
Journal Title
Multiple Sclerosis Journal
Issued Date
2018
Volume
24
Issue
3
Abstract
Background: Neuromyelitis optica spectrum disorder (NMOSD)
was rare neuroinflammatory disease, often coexists with autoantibodies
such as anti-nucleotide antibody (ANA), anti-Sjogren’s
syndrome A (SSA) antibody, anti-Sjogren’s syndrome B (SSB)
antibody, and rheumatoid factor (RF). However, the relationship
between autoantibodies and NMOSD is not clear.
Objective: We investigated the prevalence of autoantibodies and
the associations between the existence of autoantibodies and disability
in NMOSD patients.
Methods: We collected the clinical information and the profile of
autoantibodies including ANA, SSA, SSB, anti-neutrophil cytoplasmic
antibody (ANCA), anti-thyroperoxidase (TPO) antibody,
anti-thyroglobulin (TG) antibody, and RF in NMOSD patients of
11 hospitals in Korea for 3 years (2014. Sep – 2016. Nov). We
evaluated the associations between the positivity of each autoantibody
and the time from onset of NMOSD to a higher Expanded
Disability Status Scale (EDSS) score (EDSS>6.0) using coxregression
analysis.
Results: A total of 159 patients were evaluated autoantibodies, the
frequency of autoantibodies was ANA (33%), SSA (29%), TPO
(15%), TG (12%), SSB (10%), RF (9%), and ANCA (2.4%). The
median of EDSS was 3 (IQ 2-4), the mean of disease duration was
8.2 (SD 6.5) years. Higher EDSS was associated the elevation of
RF (p=0.003) and the hazard ratio of RF was 7.9 (95% CI 2.0
– 31.1).
Conclusion: Autoantibodies possibly modulate the progression of
disease in NMOSD. We confirmed that various autoantibodies
were presented and suggested that the elevation of RF may be
associated the higher disabilities in NMOSD patients.
Keimyung Author(s)(Kor)
석흥열
Publisher
School of Medicine (의과대학)
Citation
Hye Lim Lee et al. (2018). Rheumatoid Factor May Associated with Disability in Neuromyelitis Optica Spectrum Disorder. Multiple Sclerosis Journal, 24(3), 408–408. doi: 10.1177/1352458517751792
Type
Article
ISSN
1352-4585
Source
https://journals.sagepub.com/doi/full/10.1177/1352458517751792
DOI
10.1177/1352458517751792
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41445
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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