Rheumatoid Factor May Associated with Disability in Neuromyelitis Optica Spectrum Disorder
- Affiliated Author(s)
- 석흥열
- Alternative Author(s)
- Seok, Hung Youl
- Journal Title
- Multiple Sclerosis Journal
- ISSN
- 1352-4585
- Issued Date
- 2018
- Abstract
- Background: Neuromyelitis optica spectrum disorder (NMOSD)
was rare neuroinflammatory disease, often coexists with autoantibodies
such as anti-nucleotide antibody (ANA), anti-Sjogren’s
syndrome A (SSA) antibody, anti-Sjogren’s syndrome B (SSB)
antibody, and rheumatoid factor (RF). However, the relationship
between autoantibodies and NMOSD is not clear.
Objective: We investigated the prevalence of autoantibodies and
the associations between the existence of autoantibodies and disability
in NMOSD patients.
Methods: We collected the clinical information and the profile of
autoantibodies including ANA, SSA, SSB, anti-neutrophil cytoplasmic
antibody (ANCA), anti-thyroperoxidase (TPO) antibody,
anti-thyroglobulin (TG) antibody, and RF in NMOSD patients of
11 hospitals in Korea for 3 years (2014. Sep – 2016. Nov). We
evaluated the associations between the positivity of each autoantibody
and the time from onset of NMOSD to a higher Expanded
Disability Status Scale (EDSS) score (EDSS>6.0) using coxregression
analysis.
Results: A total of 159 patients were evaluated autoantibodies, the
frequency of autoantibodies was ANA (33%), SSA (29%), TPO
(15%), TG (12%), SSB (10%), RF (9%), and ANCA (2.4%). The
median of EDSS was 3 (IQ 2-4), the mean of disease duration was
8.2 (SD 6.5) years. Higher EDSS was associated the elevation of
RF (p=0.003) and the hazard ratio of RF was 7.9 (95% CI 2.0
– 31.1).
Conclusion: Autoantibodies possibly modulate the progression of
disease in NMOSD. We confirmed that various autoantibodies
were presented and suggested that the elevation of RF may be
associated the higher disabilities in NMOSD patients.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.