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Serum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites

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Author(s)
Tae Yeob KimEun Young ChoJun Sung LeeSoung Won JungJae Young JangHyonggin AnWon Young TakSoon Koo BaikJae Seok HwangYoung Seok KimJoo Hyun SohnSoon Ho UmYeon Seok SeoSoo Young ParkMoon Young KimSang Gyune KimJun Yong ParkHyung Joon YimByoung Kuk JangSeung Ha ParkJi Hoon KimKi Tae SukJin Dong Kim
Keimyung Author(s)
Hwang, Jae SeokJang, Byoung Kuk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Gastroenterology and Hepatology
Issued Date
2018
Volume
33
Issue
4
Keyword
creatininecystatin Chepatorenal syndromeliver cirrhosisrenal dysfunction
Abstract
BACKGROUND AND AIM:

Although serum cystatin C level is considered a more accurate marker of renal function in patients with liver cirrhosis, its prognostic efficacy remains uncertain. This study aimed to evaluate the prognostic efficacy of serum cystatin C level in patients with cirrhotic ascites.

METHODS:

Patients with cirrhotic ascites from 15 hospitals were prospectively enrolled between September 2009 and March 2013. Cox regression analyses were performed to identify independent predictive factors of mortality and development of type 1 hepatorenal syndrome (HRS-1).

RESULTS:

In total, 350 patients were enrolled in this study. The mean age was 55.4 ± 10.8 years, and 267 patients (76.3%) were men. The leading cause of liver cirrhosis was alcoholic liver disease (64.3%), followed by chronic viral hepatitis (29.7%). Serum creatinine and cystatin C levels were 0.9 ± 0.4 mg/dL and 1.1 ± 0.5 mg/L, respectively. Multivariate analyses revealed that international normalized ratio and serum bilirubin, sodium, and cystatin C levels were independent predictors of mortality and international normalized ratio and serum sodium and cystatin C levels were independent predictors of the development of HRS-1. Serum creatinine level was not significantly associated with mortality and development of HRS-1 on multivariate analysis.

CONCLUSION:

Serum cystatin C level was an independent predictor of mortality and development of HRS-1 in patients with cirrhotic ascites, while serum creatinine level was not. Predictive models based on serum cystatin C level instead of serum creatinine level would be more helpful in the assessment of the condition and prognosis of patients with cirrhotic ascites.
Keimyung Author(s)(Kor)
황재석
장병국
Publisher
School of Medicine (의과대학)
Citation
Tae Yeob Kim et al. (2018). Serum cystatin C level: An excellent predictor of mortality in patients with cirrhotic ascites. Journal of Gastroenterology and Hepatology, 33(4), 910–917. doi: 10.1111/jgh.13983
Type
Article
ISSN
0815-9319
Source
https://onlinelibrary.wiley.com/doi/full/10.1111/jgh.13983
DOI
10.1111/jgh.13983
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41470
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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