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Targeted therapy of ovarian cancer including immune check point inhibitor

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Author(s)
Jin Young KimChi Heum ChoHong Suk Song
Keimyung Author(s)
Cho, Chi HeumKim, Jin YoungSong, Hong Suk
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2017
Volume
32
Issue
5
Keyword
ImmunotherapyMolecular targeted therapyOvarian neopla는
Abstract
Epithelial ovarian cancer is the eighth most common cause of cancer-related deaths in women because most patients present with advanced stage disease at the time of diagnosis. Although cytoreductive surgery and platinum-based chemotherapy remain the gold standards of treatment, the recurrence rate of ovarian cancer remains high. Attempts to improve this standard two-drug chemotherapy by adding a third cytotoxic drug have failed to affect either progression-free survival or overall survival and have resulted in an increase in toxic side effects. Some anti-angiogenic agents, poly(ADP-ribose) polymerase, and immune checkpoint inhibitors have shown efficacy in early stages of development for the treatment of epithelial ovarian cancer. As demonstrated in recent clinical trials, the use of bevacizumab, cediranib, pazopanib, olaparib, and rucaparib, either alone or in combination with conventional cytotoxic agents, improves progression-free survival. Trials on immune checkpoint inhibitors such as nivolumab have revealed prolonged responses in a small set of ovarian cancer cases but require further exploration. In this review, we discuss the role of targeted therapies against ovarian cancer, including the use of immune checkpoint inhibitors.
Keimyung Author(s)(Kor)
조치흠
김진영
송홍석
Publisher
School of Medicine (의과대학)
Citation
Jin Young Kim et al. (2017). Targeted therapy of ovarian cancer including immune check point inhibitor. Korean Journal of Internal Medicine, 32(5), 798–804. doi: 10.3904/kjim.2017.008
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2017.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41496
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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