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TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

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Author(s)
Hye Won LeeWon-Jin ParkYu-Ran HeoTae In ParkSoo Young ParkJae-Ho Lee
Keimyung Author(s)
Lee, Jae HoLee, Hye Won
Department
Dept. of Anatomy (해부학)
Dept. of Pathology (병리학)
Journal Title
OncoTargets and Therapy
Issued Date
2017
Volume
10
Keyword
CLPTM1L polymorphismTERT-CLPTM1L locushepatocellular carcinomatelomere length
Abstract
Telomere length is associated with the development of hepatocellular carcinoma (HCC), and recent studies have focused on the genetic alteration or polymorphism in telomere-maintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD =1.32), and there were no differences in telomere length according to rs401681 polymorphism (p=0.802). Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01). Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01). In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients.
Keimyung Author(s)(Kor)
이재호
이혜원
Publisher
School of Medicine (의과대학)
Citation
Hye Won Lee et al. (2017). TERT-CLPTM1 locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma. OncoTargets and Therapy, 10, 4853–4858. doi: 10.2147/OTT.S138956
Type
Article
ISSN
1178-6930
DOI
10.2147/OTT.S138956
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41505
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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