The clinical significance of tumor infiltrating lymphocytes in early breast cancer patients
- Author(s)
- M.H. Lee; S.Y. Kwon; J. Cho; S.H. Kang
- Keimyung Author(s)
- Kwon, Sun Young; Kang, Sun Hee; Cho, Ji Hyoung; Lee, Moo Hyun
- Department
- Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
- Journal Title
- European Journal of Cancer
- Issued Date
- 2018
- Volume
- 92
- Issue
- suppl.3
- Abstract
- Background: Tumor infiltrating lymphocytes (TILs) are commonly detected
in breast tumors but their clinical significance in breast cancer remains
controversial. This study was conducted to assess the correlation between
the level of TILs and other clinicopathologic parameters in early breast
cancer patients.
Material and Methods: The level of TILs was assessed by hematoxylin
and eosin staining of primary tumor from 112 patients with stage I-III breast
cancer. The level of TILs was analyzed in tumor nests, in stroma adjacent to
tumor cells, and in stroma distant to tumor cells, and their relationship with
clinicopathologic parameters was determined. The patients were divided into
four subtypes for analyses, according to estrogen receptor (ER) and HER2
status: (1) ER+/HER2–, (2) ER+/HER2+, (3) ER-/HER2+, and (4) ER–/
HER2–.
Results: The majority of the patients had an ER+/HER2− breast cancer
(58.9%); 63 patients presented with a grade 3 tumor (56.3%). Twenty-nine
percent of the patients had node-positive disease and 27% patients
presented with tumors larger than 2 cm. Median level of TILs was 3%.
Higher level of TILs (≥3%) was associated with tumor size ≥ 2cm, positive
nodes and histologic grade ≥ 3, negative ER status and positive HER2 status
(p = 0.029, 0.032, <0.001, <0.001 and 0.001). ER+/HER2− subtype had
significantly lower level of TILs compared with other subtypes (p < 0.001).
Conclusions: Our results demonstrated that higher level of TILs was
associated with unfavorable clinicopathologic parameters. The level of TILs
was low in ER+/HER2− subtype compared with other subtypes. The level of
TILs could be potential prognostic parameter in breast cancer patients.
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