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The clinical significance of tumor infiltrating lymphocytes in early breast cancer patients

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Author(s)
M.H. LeeS.Y. KwonJ. ChoS.H. Kang
Keimyung Author(s)
Kwon, Sun YoungKang, Sun HeeCho, Ji HyoungLee, Moo Hyun
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Journal Title
European Journal of Cancer
Issued Date
2018
Volume
92
Issue
suppl.3
Abstract
Background: Tumor infiltrating lymphocytes (TILs) are commonly detected
in breast tumors but their clinical significance in breast cancer remains
controversial. This study was conducted to assess the correlation between
the level of TILs and other clinicopathologic parameters in early breast
cancer patients.
Material and Methods: The level of TILs was assessed by hematoxylin
and eosin staining of primary tumor from 112 patients with stage I-III breast
cancer. The level of TILs was analyzed in tumor nests, in stroma adjacent to
tumor cells, and in stroma distant to tumor cells, and their relationship with
clinicopathologic parameters was determined. The patients were divided into
four subtypes for analyses, according to estrogen receptor (ER) and HER2
status: (1) ER+/HER2–, (2) ER+/HER2+, (3) ER-/HER2+, and (4) ER–/
HER2–.
Results: The majority of the patients had an ER+/HER2− breast cancer
(58.9%); 63 patients presented with a grade 3 tumor (56.3%). Twenty-nine
percent of the patients had node-positive disease and 27% patients
presented with tumors larger than 2 cm. Median level of TILs was 3%.
Higher level of TILs (≥3%) was associated with tumor size ≥ 2cm, positive
nodes and histologic grade ≥ 3, negative ER status and positive HER2 status
(p = 0.029, 0.032, <0.001, <0.001 and 0.001). ER+/HER2− subtype had
significantly lower level of TILs compared with other subtypes (p < 0.001).
Conclusions: Our results demonstrated that higher level of TILs was
associated with unfavorable clinicopathologic parameters. The level of TILs
was low in ER+/HER2− subtype compared with other subtypes. The level of
TILs could be potential prognostic parameter in breast cancer patients.
Keimyung Author(s)(Kor)
권선영
강선희
조지형
이무현
Publisher
School of Medicine (의과대학)
Citation
M.H. Lee et al. (2018). The clinical significance of tumor infiltrating lymphocytes in early breast cancer patients. European Journal of Cancer, 92(suppl.3), S142–S142. doi: 10.1016/S0959-8049(18)30651-8
Type
Article
ISSN
0959-8049
Source
https://www.ejcancer.com/article/S0959-8049(18)30651-8/abstract
DOI
10.1016/S0959-8049(18)30651-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41512
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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