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The effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 release during femtosecond laser-assisted cataract surgery

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Author(s)
Jong Hwa JunYoung-Sik YooSung A. LimChoun-Ki Joo
Keimyung Author(s)
Jun, Jong Hwa
Department
Dept. of Ophthalmology (안과학)
Journal Title
Journal of Cataract and Refractive Surgery
Issued Date
2017
Volume
43
Issue
4
Abstract
PURPOSE:

To determine the effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 (PGE2) release during femtosecond laser-assisted cataract surgery.

SETTING:

Seoul St. Mary's Hospital, Seoul, Korea.

DESIGN:

Prospective case series.

METHODS:

The study comprised the following 3 groups: conventional cataract surgery without topical NSAIDs (conventional group); femtosecond laser-assisted cataract surgery with preoperative topical ketorolac tromethamine 0.45% (femtosecond NSAID group), and femtosecond laser-assisted cataract surgery without topical NSAIDs (femtosecond no-NSAID group). To measure the aqueous humor PGE2 concentration, a 100 μL aqueous humor sample was collected from the anterior chamber after femtosecond laser pretreatment. The PGE2 concentration was measured using an enzyme immunoassay.

RESULTS:

Topical ketorolac tromethamine 0.45% led to a significant reduction in intraoperative miosis in the femtosecond NSAID group compared with the femtosecond no-NSAID group (P < .001). Absolute and relative reductions in pupil area in the femtosecond NSAID group were significantly lower than in the femtosecond no-NSAID group (P = .019 and P = .007, respectively). The mean aqueous humor PGE2 concentrations were 893.60 pg/mL ± 843.10 (SD) in the conventional group, 1911.43 ± 1178.63 pg/mL in the femtosecond NSAID group, and 743.63 ± 927.46 pg/mL in the femtosecond no-NSAID group (P < .001, conventional versus femtosecond NSAID and femtosecond NSAID versus femtosecond no NSAID; P > .05, conventional versus femtosecond NSAID).

CONCLUSION:

Preoperative topical ketorolac tromethamine 0.45% reduced miosis induced by femtosecond laser pretreatment and inhibited aqueous humor PGE2 elevation.
Keimyung Author(s)(Kor)
전종화
Publisher
School of Medicine (의과대학)
Citation
Jong Hwa Jun et al. (2017). The effects of topical 0.45% ketorolac tromethamine on intraoperative miosis and prostaglandin E2 release during femtosecond laser-assisted cataract surgery. Journal of Cataract and Refractive Surgery, 43(4), 492–497. doi: 10.1016/j.jcrs.2017.01.011
Type
Article
ISSN
0886-3350
Source
https://linkinghub.elsevier.com/retrieve/pii/S0886-3350(17)30123-2
DOI
10.1016/j.jcrs.2017.01.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41522
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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