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The influence of high-dose intraoperative remifentanil on postoperative sore throat

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Author(s)
Ji-Hoon ParkYong-Cheol LeeJiwon LeeHyunjae KimHyun-Chang Kim
Keimyung Author(s)
Lee, Yong CheolLee, Ji WonKim, Hyun Chang
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Medicine
Issued Date
2018
Volume
97
Issue
50
Keyword
intubationpainpharyngitispostoperativeremifentanil
Abstract
Background: Endotracheal intubation for general anesthesia causes postoperative sore throat (POST). This study is designed to
evaluate the effect of high-dose remifentanil on the incidence of POST in patients after general anesthesia.
Methods:Ninety-two patients scheduled for orthopedic lower extremity surgery under general anesthesia were randomly assigned
into 1 of 2 groups. In the high-dose remifentanil (HR) group (n=46), remifentanil was infused at a rate of 0.25mg/kg/min and
subsequently increased or decreased by 0.05mg/kg/min per clinical demand. In the low-dose remifentanil (LR) group (n=46),
remifentanil was infused at a rate of 0.05mg/kg/min. The incidence of POST was monitored at 0, 2, 4, and 24 hours postoperatively.
Complications regarding opioids were compared between groups.
Results: The overall incidence of POST was higher in the HR group compared with that in the LR group [33 (72%) vs 18 (39%),
P=.022]. The incidence of POST at 0, 2, and 24hours after surgery was higher in the HR group compared with that in the LR group
(P<.001, P=.001, and P=.001, respectively). The incidence of postoperative nausea, vomiting, drowsiness, and headache was
similar between the groups. The incidence of postoperative shivering was higher in the HR group than in the LR group [10 (22%) vs 2
(4%), difference 17%, 95% CI 2%–33%, P=.027].
Conclusion:A relatively large dose of intraoperative remifentanil increased the incidence of POST in patients for orthopedic surgery
under general anesthesia.
Trial Registration: Clinicaltrials.gov Identifier: NCT03173339.
Abbreviations: ETT = endotracheal tube, HR = high-dose remifentanil, IQR = interquatile rage, LR = low-dose remifentanil, MAC
= minimum alveolar concentration, POST = postoperative sore throat.
Keimyung Author(s)(Kor)
이용철
이지원
김현창
Publisher
School of Medicine (의과대학)
Citation
Ji-Hoon Park et al. (2018). The influence of high-dose intraoperative remifentanil on postoperative sore throat. Medicine, 97(50), e13510–e13510. doi: 10.1097/MD.0000000000013510
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000013510
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41530
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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