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The Neutrophil-Lymphocyte Ratio Predicts Recurrence of Cervical Intraepithelial Neoplasia

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Author(s)
Sungwook ChunKyusik ShinKi Hyung KimHeung Yeol KimWankyu EoJi Young LeeJeong NamkungSang Hoon KwonSuk Bong KohHong-Bae Kim
Keimyung Author(s)
Kwon, Sang Hoon
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Journal of Cancer
Issued Date
2017
Volume
8
Issue
12
Keyword
Cervical Intraepithelial NeoplasiaEosinophilLymphocyteNeutrophilRecurrence
Abstract
OBJECTIVE: The purpose of the present study was to determine the prognostic significance of the neutrophil-lymphocyte ratio (NLR) in recurrence of cervical intraepithelial neoplasia (CIN). METHODS: We evaluated the NLR as a prognostic marker in the entire cohort of 230 patients who had undergone surgical resection and were diagnosed with CIN. Subjects were categorized into two different groups based on the NLR (NLR-high and NLR-low) using cutoff values determined by receiver operating characteristic (ROC) analysis. The primary research objective for this study was to validate the impact of the NLR on recurrence-free survival (RFS) in patients with CIN. The secondary objective was to evaluate the impact of other hematologic parameters on RFS in CIN patients. RESULTS: Using the entire cohort, the most appropriate NLR cut-off value for CIN recurrence selected on the ROC curve was 2.1. The NLR-low and NLR-high groups included 167 (72.6%) and 63 patients (27.4%), respectively. According to Kaplan-Meier analysis, RFS rates during the entire follow-up period were considerably lower in the NLR-high group than in the NLR-low group (P = 0.0125). In multivariate survival analysis using Cox proportional hazard model, we identified the NLR, absolute eosinophil count (AEC), hemoglobin concentration, and mean corpuscular volume (MCV) as valuable prognostic factors that impact RFS. CONCLUSIONS: The NLR is an independent prognosticator for RFS following surgical resection in CIN patients. We also found that the AEC, hemoglobin level, and MCV were strongly associated with RFS, as determined by multivariate analysis using a Cox model. These hematological parameters might provide additional prognostic value beyond that offered by standard clinicopathologic parameters.
Keimyung Author(s)(Kor)
권상훈
Publisher
School of Medicine (의과대학)
Citation
Sungwook Chun et al. (2017). The Neutrophil-Lymphocyte Ratio Predicts Recurrence of Cervical Intraepithelial Neoplasia. Journal of Cancer, 8(12), 2205–2211. doi: 10.7150/jca.19173
Type
Article
ISSN
1837-9664
DOI
10.7150/jca.19173
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41533
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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