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The Role of radiation therapy in primary central nervous system lymphoma : KROG 14-20 Collaborative Study of Brain and Lymphoma Committee

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Author(s)
Hyeon Kang KohIl Han KimTae Min KimDo Hoon LimDongryul OhJae Ho ChoWoo‑Chul KimJin Hee KimWoong‑Ki ChungBae‑Kwon JeongKi Mun KangSemie HongChang‑Ok SuhIn Ah Kim
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Journal of Neuro-Oncology
Issued Date
2017
Volume
135
Issue
3
Keyword
Central nervous systemLymphomaMethotrexateRadiotherapy
Abstract
We analyzed patterns of care and outcomes for patients with primary central nervous system lymphoma (PCNSL) in this multi-institutional retrospective study. Between January 2000 and December 2011, 220 patients with PCNSL received radiotherapy (RT). Among these patients, 26 patients received RT alone; 179 patients were treated with chemotherapy and radiotherapy; the rest of the patients (N = 15) initially underwent chemotherapy alone, then received RT as a salvage treatment. Most of the patients (N = 188) received methotrexate-based chemotherapy. The median follow up duration was 38 months (range 3-179 months). The median RT dose and whole brain RT (WBRT) dose were 45.0 Gy (range 20.0-59.4) and 30.6 Gy (range 18.0-45.0), respectively. Seventy-seven (35%) patients received WBRT alone, and 143 patients (65%) underwent WBRT plus boost RT. Total RT dose and WBRT dose decreased during the study period. The median survival was 64 months and actuarial 5-year overall survival was 51.4%. In multivariate analysis, age (P < 0.001), ECOG performance status (P = 0.036), deep structure involvement (P = 0.011) and treatment response (P = 0.001) were significant prognosticators. RT combined with chemotherapy is effective modality for treatment of PCNSL. The survival outcome improved in spite of total radiation dose and whole brain RT (WBRT) dose having been decreased over the study period, indicating that low-dose WBRT could be effective.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Hyeon Kang Koh et al. (2017). The Role of radiation therapy in primary central nervous system lymphoma : KROG 14-20 Collaborative Study of Brain and Lymphoma Committee. Journal of Neuro-Oncology, 135(3), 629–638. doi: 10.1007/s11060-017-2616-4
Type
Article
ISSN
0167-594X
Source
https://link.springer.com/article/10.1007%2Fs11060-017-2616-4
DOI
10.1007/s11060-017-2616-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41543
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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