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Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis.

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Author(s)
Chang Seok BangJae Myung ParkGwang Ho BaikJong Jae ParkMoon Kyung JooJae Young JangSeong Woo JeonSuck Chei ChoiJae Kyu SungKwang Bum Cho
Keimyung Author(s)
Cho, Kwang Bum
Department
Dept. of Internal Medicine (내과학)
Journal Title
Clinical Endoscopy
Issued Date
2017
Volume
50
Issue
6
Keyword
Endoscopic mucosal resectionStomach neoplasmsUndifferentiated
Abstract
BACKGROUND/AIMS:

To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology.

METHODS:

Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed.

RESULTS:

From 2006 to 2015, 275 EGCs with undifferentiated-type histology from 275 patients were identified. The immediate outcomes were as follows: en bloc resection rate: 92.4%; complete resection rate: 80%; and curative resection rate: 36.4%. Compared to patients with lesions that were beyond the expanded indication, those with expanded indication lesions showed better therapeutic outcomes. There was no difference in immediate outcomes between patients with poorly differentiated adenocarcinoma (PDC) and signet ring cell carcinoma (SRC). However, compared to ER of SRC, ER of PDC had a stronger association with submucosal invasion (41.9% vs. 23.6%, p=0.003). With regard to long-term outcomes, there was no difference between lesions with curative and non-curative resections in the recurrence and mortality rates. These rates also did not differ between PDC and SRC (median follow up: 3.96 years).

CONCLUSIONS:

ER confined to expanded indication lesions can be considered for treatment of EGC with undifferentiated-type histology.
Keimyung Author(s)(Kor)
조광범
Publisher
School of Medicine (의과대학)
Citation
Chang Seok Bang et al. (2017). Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis. Clinical Endoscopy, 50(6), 569–577. doi: 10.5946/ce.2017.017
Type
Article
ISSN
2234-2400
DOI
10.5946/ce.2017.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41546
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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