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Tumor Boost Using External Beam Radiation in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy Outcome From a Multicenter Retrospective Study (Korean Radiation Oncology Group 1419)

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Author(s)
Haeyoung KimYoung Seok KimJi Hyeon JooKeun-Yong EomWon ParkJin Hee KimJong Hoon LeeYeon Sil KimSeok Ho LeeKijung AhnYong Bae KimMe-Yeon LeSei Kyung Chang
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
International Journal of Gynecological Cancer
Issued Date
2018
Volume
28
Issue
2
Keyword
BrachytherapyRadiotherapyUterine cervical neoplasm
Abstract
PURPOSE:

We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy.

METHODS:

A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012.

RESULTS:

A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B. Initial tumor responses assessed at 2 to 6 months after radiotherapy were as follows: 46 with complete response, 22 with partial response, 2 with stable disease, and 3 with progressive disease. After a median follow-up time of 33 months, 30 patients (40.0%) showed disease progression including 21 (28.0%) with local progression. The 5-year local failure-free survival rate was 70.0%. Achieving complete response at the first follow-up visit and an overall treatment time of 53 days or less were significantly related to favorable local failure-free survival. The rate of grade 3 or higher toxicity was 2.6%.

CONCLUSIONS:

Approximately 70% of patients had local tumor control after curative radiotherapy using EBRT-B. Early tumor response and overall treatment time of 53 days or less were closely associated with favorable local control.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Haeyoung Kim et al. (2018). Tumor Boost Using External Beam Radiation in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy Outcome From a Multicenter Retrospective Study (Korean Radiation Oncology Group 1419). International Journal of Gynecological Cancer, 28(2), 371–378. doi: 10.1097/IGC.0000000000001155
Type
Article
ISSN
1048-891X
Source
https://ijgc.bmj.com/content/28/2/371
DOI
10.1097/IGC.0000000000001155
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41561
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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