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새로운 non-apoptotic 세포사멸: ferroptosis

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Author(s)
우선민권택규
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Yeungnam University Journal of Medicine
Issued Date
2017
Volume
34
Issue
2
Keyword
FerroptosisNon-apoptotic cell deathIron-dependent cell deathReactive oxygen species
Abstract
Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic cell death. This type of cell death is characterized by mitochondrial shrinkage with an increased mitochondrial membrane density and outer mitochondrial membrane rupture. Ferroptosis can be induced by a loss of activity of system Xc - and the inhibition of glutathione peroxidase 4, followed by the accumulation of lipid reactive oxygen species (ROS). In addition, inactivation of the mevalonate and transsulfuration pathways is involved in the induction of ferroptosis. Moreover, nicotinamide adenine dinucleotide phosphate oxidase and p53 promote ferroptosis by increasing ROS production, while heat shock protein beta-1 and nuclear factor erythroid 2-related factor 2 inhibit ferroptosis by reducing iron uptake. This article outlines the molecular mechanisms and signaling pathways of ferroptosis regulation, and explains the roles of ferroptosis in human disease
Alternative Title
Novel non-apoptotic cell death: ferroptosis
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Citation
우선민 and 권택규. (2017). 새로운 non-apoptotic 세포사멸: ferroptosis. Yeungnam University Journal of Medicine, 34(2), 174–181. doi: 10.12701/yujm.2017.34.2.174
Type
Article
ISSN
2384-0293
DOI
10.12701/yujm.2017.34.2.174
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41604
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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