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주의력결핍-과잉행동장애와 Corticotropin releasing hormone receptor 1 (CRHR1) 유전자 다형성의 관련성 연구

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Author(s)
박주연김나현김대광
Keimyung Author(s)
Kim, Dae KwangKim, Na Hyun
Department
Dept. of Medical Education (의학교육학)
Dept. of Nursing (간호학)
Journal Title
예술인문사회 융합 멀티미디어 논문지
Issued Date
2018
Volume
8
Issue
4
Keyword
Attention deficit-hyperactivity disordergene polymorphismCRHR1rs110402
Abstract
Attention deficit hyperactivity disorder (ADHD) is known to be associated with a variety of risk factors, such as personal characteristics, psychosocial, neurologic, and physiological factor. Few studies have examined the genetic factors related to ADHD. In recent studies, ADHD may be associated to hypothalamus–pituitary–adrenal axis (HPA axis) activity. Corticotropin releasing hormone receptor 1 (CRHR1) gene is an important regulator of system of the HPA axis, we selected CRHR1 gene (rs110402) as candidated gene for ADHD. 107 ADHD patients and 106 normal newborns were used as frozen DNA. For analysis, CRHR1 (rs110402) gene was genotyped by Single strand conformation polymorphism analysis (SSCP). The genotype and allele distribution of CRHR1 (rs110402) gene polymorphism in ADHD group and normal control group were analyzed. As a result, ADHD and CRHR1 gene polymorphism showed significant differences in genotype and allele distribution. Plymorphism of CRHR1 may play an importatn role in ADHD in the Korean.
Alternative Title
Association between Corticotropin Releasing Hormone Receptor 1 Gene Polymorphism and Attention Deficit Hyperactivity Disorder
Keimyung Author(s)(Kor)
김대광
김나현
Publisher
School of Medicine (의과대학)
College of Nursing (간호대학)
Citation
박주연 et al. (2018). 주의력결핍-과잉행동장애와 Corticotropin releasing hormone receptor 1 (CRHR1) 유전자 다형성의 관련성 연구. 예술인문사회 융합 멀티미디어 논문지, 8(4), 753–760. doi: 10.21742/AJMAHS.2018.04.41
Type
Article
ISSN
2383-5281
Source
http://scholar.dkyobobook.co.kr/searchDetail.laf?barcode=4050026409697
DOI
10.21742/AJMAHS.2018.04.41
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41616
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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