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The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus

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Author(s)
Chang-Nam SonTae-Han LeeJi-Hye BangHye-Jin JeongJin-Nyeong ChaeWon-Mok LeeJi-Min KimSang-Hyon Kim
Keimyung Author(s)
Kim, Ji MinKim, Sang HyonSon, Chang NamLee, Won Mok
Department
Dept. of Internal Medicine (내과학)
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Korean J Intern Med
Issued Date
2018
Volume
33
Issue
4
Keyword
Systemic lupus erythematosusAnti-C-reactive protein antibody
Abstract
Background/Aims
Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE.

Methods
This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE.

Results
The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 µg/mL vs. 9.1 ± 2.8 µg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers.

Conclusions
These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.
Keimyung Author(s)(Kor)
손창남
이원목
김지민
김상현
Publisher
School of Medicine (의과대학)
Citation
Chang-Nam Son et al. (2018). The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus. Korean J Intern Med, 33(4), 823–828. doi: 10.3904/kjim.2016.065
Type
Article
ISSN
1226-3303
Source
http://kjim.org/journal/view.php?doi=10.3904/kjim.2016.065
DOI
10.3904/kjim.2016.065
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41681
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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